138 A chemical strategy that leads to selective destruction of proteins of interest may be a valuable tool for drug development.
http://www.sciencemag.org/content/348/6241/1376.abstract
137 A griselimycin-derived drug that blocks the DNA polymerase sliding clamp is a potent anti-tuberculosis lead.
http://www.sciencemag.org/content/348/6239/1106.abstract
136 Shaping mycolactone for therapeutic use against inflammatory disorders.
http://stm.sciencemag.org/content/7/289/289ra85
135 Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.
http://stm.sciencemag.org/content/7/288/288ra75
134 NMDA receptors in pancreatic beta cells inhibit glucose-stimulated insulin secretion, and inhibiting these receptors with an over-the-counter medication improves diabetes in mouse models.
http://www.nature.com/nm/journal/v21/n4/abs/nm.3822.html
133 Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
http://www.nature.com/ncomms/2015/150331/ncomms7715/full/ncomms7715.html
132 Plant-derived antifungal agent poacic acid targets β-1,3-glucan.
http://www.pnas.org/content/112/12/E1490.abstract
131 Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design.
http://www.nature.com/ncomms/2015/150320/ncomms7582/full/ncomms7582.html
130 Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease.
http://www.nejm.org/doi/full/10.1056/NEJMoa1407250
129 Total synthesis of clostrubin.
http://www.nature.com/ncomms/2015/150311/ncomms7445/full/ncomms7445.html
128 A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
http://www.nature.com/nm/journal/v21/n3/abs/nm.3806.html
127 Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.
http://www.pnas.org/content/112/9/2847.abstract
126 Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.
http://jem.rupress.org/content/212/2/129.abstract
125 Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma.
http://www.nejm.org/doi/full/10.1056/NEJMoa1411321
124 Sodium Zirconium Cyclosilicate in Hyperkalemia.
http://www.nejm.org/doi/full/10.1056/NEJMoa1411487
123 Learning to identify CNS drug action and efficacy using multistudy fMRI data.
http://stm.sciencemag.org/content/7/274/274ra16
122 Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.
http://www.nature.com/nchembio/journal/v11/n2/abs/nchembio.1710.html
121 Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.
http://www.nature.com/nature/journal/v518/n7537/full/nature14137.html
120 A new antibiotic kills pathogens without detectable resistance.
http://www.nature.com/nature/journal/v517/n7535/full/nature14098.html
119 In vivo anticancer activity of rhomboidal Pt(II) metallacycles.
http://www.pnas.org/content/111/52/18448.abstract
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