Cancer Biology

 
1044 Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function
https://stke.sciencemag.org/content/12/590/eaaw7095

1043 Engineering nanoparticles to locally activate T cells in the tumor microenvironment.
https://immunology.sciencemag.org/content/4/37/eaau6584

1042 Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor.
https://science.sciencemag.org/content/365/6449/162

1041 Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.
https://www.pnas.org/content/116/28/14181

1040 dTcf/Pangolin suppresses growth and tumor formation in Drosophila.
https://www.pnas.org/content/116/28/14055

1039 UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.
https://www.nature.com/articles/s41586-019-1340-y

1038 Programmable bacteria induce durable tumor regression and systemic antitumor immunity.
https://www.nature.com/articles/s41591-019-0498-z

1037 Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30186-X

1036 Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.
https://www.cell.com/immunity/fulltext/S1074-7613(19)30190-6

1035 Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30630-0

1034 A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.
https://www.cell.com/cell/fulltext/S0092-8674(19)30556-2

1033 Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30510-0

1032 Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.
https://stm.sciencemag.org/content/11/498/eaaw2614

1031 An analysis of more than 2500 human tumors reveals that cancer driver and passenger mutations can be identified from mesoscale genomic context.
https://science.sciencemag.org/content/364/6447/eaaw2872

1030 A Mucin 16 bispecific T cell–engaging antibody for the treatment of ovarian cancer.
https://stm.sciencemag.org/content/11/497/eaau7534

1029 The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
https://science.sciencemag.org/content/364/6446/1156

1028 A new anti-CD19 CAR T cell therapy induces potent antitumor responses without causing severe cytokine-release syndrome or neurotoxicity in patients with lymphoma.
https://www.nature.com/articles/s41591-019-0421-7

1027 Genome-wide cell-free DNA fragmentation in patients with cancer.
https://www.nature.com/articles/s41586-019-1272-6

1026 In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.
https://stm.sciencemag.org/content/11/496/eaat5857

1025 Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
https://stm.sciencemag.org/content/11/496/eaav5989

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