Cancer Biology

 
1068 E-cadherin is required for metastasis in multiple models of breast cancer.
https://www.nature.com/articles/s41586-019-1526-3

1067 Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases.
https://stm.sciencemag.org/content/11/509/eaaw8513

1066 Collagen-binding ability improves serum albumin as an anti-cancer drug carrier, resulting in enhanced therapeutic efficacy.
https://advances.sciencemag.org/content/5/8/eaaw6081

1065 A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.
https://advances.sciencemag.org/content/5/8/eaav6789

1064 A cell-penetrating fluorescent marker is used to label cells in the metastatic tumour microenvironment, revealing a variety of cell types including parenchymal cells with lung stem-cell characteristics.
https://www.nature.com/articles/s41586-019-1487-6

1063 Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30188-3

1062 Mesoporous Silica as a Versatile Platform for Cancer Immunotherapy.
https://onlinelibrary.wiley.com/doi/10.1002/adma.201803953

1061 Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy.
https://onlinelibrary.wiley.com/doi/10.1002/adma.201803322

1060 Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.
https://www.cell.com/cell/fulltext/S0092-8674(19)30773-1

1059 Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.
https://www.nature.com/articles/s41586-019-1450-6

1058 Repurposing dasatinib for diffuse large B cell lymphoma.
https://www.pnas.org/content/116/34/16981

1057 Proper dosing and timing of EGFR TKI can trigger antitumor T cell responses and potentiate anti–PD-L1 immunotherapy.
https://immunology.sciencemag.org/content/4/38/eaav6473

1056 Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling.
https://www.nature.com/articles/s41586-019-1426-6

1055 Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
https://www.nature.com/articles/s41586-019-1437-3

1054 CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
https://www.nature.com/articles/s41586-019-1456-0

1053 A tumor-targeted immune checkpoint blocker.
https://www.pnas.org/content/116/32/15889

1052 Resolving medulloblastoma cellular architecture by single-cell genomics.
https://www.nature.com/articles/s41586-019-1434-6

1051 Flower isoforms promote competitive growth in cancer.
https://www.nature.com/articles/s41586-019-1429-3

1050 CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.
https://www.pnas.org/content/116/31/15635

1049 Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers.
https://www.pnas.org/content/116/31/15524

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