Cancer Biology

 
1199 In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.
https://www.nature.com/articles/s41586-020-03147-x

1198 Fragmentation patterns of cell-free DNA from urine differ between healthy individuals and those with cancer.
https://stm.sciencemag.org/content/13/581/eaaz3088

1197 Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles.
https://www.pnas.org/content/118/7/e2020575118

1196 Percutaneous liquid ablation agent for tumor treatment and drug delivery.
https://stm.sciencemag.org/content/13/580/eabe3889

1195 Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling.
https://www.pnas.org/content/118/6/e2005191118

1194 Resistance to immunotherapy can be overcome using fecal microbiota transplantation for patients with metastatic melanoma.
https://science.sciencemag.org/content/371/6529/602

1193 Expression of the Epstein–Barr virus protein LMP1 in B cells increases expression of—and promotes T cell responses to—tumour-associated antigens, delineating a mechanism of infection-induced anti-tumour immunity, which could inform immune-based approaches to cancer treatment.
https://www.nature.com/articles/s41586-020-03075-w

1192 Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy.
https://www.pnas.org/content/118/5/e2017421118

1191 Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
https://www.pnas.org/content/118/5/e2020478118

1190 ACE2 is protective against renal cancer, and its down-modulation by inhibitors of VEGF receptor signaling may mediate resistance to such inhibitors.
https://stm.sciencemag.org/content/13/577/eabc0170

1189 Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer.
https://stm.sciencemag.org/content/13/575/eaba6110

1188 Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9

1187 Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
https://www.nature.com/articles/s41586-020-2911-7

1186 The dose threshold for nanoparticle tumour delivery.
https://www.nature.com/articles/s41563-020-0755-z

1185 Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202005295

1184 Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
https://www.pnas.org/content/117/48/30670

1183 Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
https://www.pnas.org/content/117/48/30566

1182 Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy.
https://stm.sciencemag.org/content/12/571/eaaz6667

1181 Systemic cancer therapy with engineered adenovirus that evades innate immunity.
https://stm.sciencemag.org/content/12/571/eabc6659

1180 CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response.
https://www.pnas.org/content/117/46/28960

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