1017 Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.
https://www.nature.com/articles/s41591-019-0423-5
1016 Preventable Cancer Burden Associated with Poor Diet in the United States.
https://academic.oup.com/jncics/advance-article/doi/10.1093/jncics/pkz034/5492023?searchresult=1
1015 Patient data from six clinical trials are used to compare the genomic landscapes of breast cancer metastases with those of primary tumours, revealing an increase in mutational burden and clonal diversity.
https://www.nature.com/articles/s41586-019-1056-z
1014 Next-generation characterization of the Cancer Cell Line Encyclopedia.
https://www.nature.com/articles/s41586-019-1186-3
1013 PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
https://www.pnas.org/content/116/20/9999
1012 Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
https://science.sciencemag.org/content/364/6441/eaau0159
1011 Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.
https://www.cell.com/cell/fulltext/S0092-8674(19)30292-2
1010 ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
https://www.nature.com/articles/s41556-019-0305-6
1009 Engineered immune cells as highly sensitive cancer diagnostics.
https://www.nature.com/articles/s41587-019-0064-8
1008 Interferon-γ induces ferroptotic cell death in tumours by suppressing cystine uptake and promoting lipid peroxidation.
https://www.nature.com/articles/s41586-019-1170-y
1007 Effective PD-1 immunotherapy is influenced by the intensity of tumor microsatellite instability.
https://science.sciencemag.org/content/364/6439/485
1006 In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new target for cancer drug development.
https://www.nature.com/articles/s41586-019-1103-9
1005 A subtype of conventional dendritic cells, cDC2, are able to prime CD4+ T cells for antitumor functions and the presence of cDC2 in human cancer samples may serve as a predictive biomarker for survival and response to immune checkpoint blockade.
https://www.cell.com/cell/fulltext/S0092-8674(19)30154-0
1004 Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state.
https://stm.sciencemag.org/content/11/488/eaav0936
1003 Why does tumor-suppressor BAP1 lead to cancer only in specific tissues?
https://science.sciencemag.org/content/364/6437/283
1002 Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.
https://www.nature.com/articles/s41586-019-1062-1
1001 Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
https://www.nature.com/articles/s41586-019-1005-x
1000 Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice.
https://www.nature.com/articles/s41467-019-09525-y
999 Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.
https://www.nature.com/articles/s41556-019-0298-1
998 Chimeric antigen receptors (CARs) promote antigen loss in tumour cells by trogocytosis, which results in T cell fratricide killing and exhaustion but can be counteracted by cooperative killing and combinatorial targeting.
https://www.nature.com/articles/s41586-019-1054-1
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