Cancer Biology

1082 Pan-cancer whole-genome analyses of metastatic solid tumours.

1081 The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

1080 Small cell lung cancer tumors are sensitive to DHODH inhibition, highlighting a potential treatment strategy for this disease.

1079 Some breast cancers harbor not one—but two—PIK3CA mutations, and this enhances their response to certain drugs.

1078 The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.

1077 n a mouse tumour model, immunotherapy-induced rejection of tumour cells requires presentation of both MHC class I and MHC class II antigens, which activate CD4+ and CD8+ T cells, respectively.

1076 A highly recurrent A>C somatic mutation in U1 small nuclear RNA, which alters the splicing pattern of genes that include known drivers of cancer, is identified in several types of tumour.

1075 Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.

1074 PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.

1073 Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.

1072 Analyses of transcriptomes from patients with acute myeloid leukaemia identified frequently co-occurring mutations of IDH2 and SRSF2, which functional analyses showed to have distinct and coordinated leukaemogenic effects on the epigenome and RNA splicing.

1071 Inducing and exploiting vulnerabilities for the treatment of liver cancer.

1070 Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.

1069 α-Ketoglutarate links p53 to cell fate during tumour suppression.

1068 E-cadherin is required for metastasis in multiple models of breast cancer.

1067 Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases.

1066 Collagen-binding ability improves serum albumin as an anti-cancer drug carrier, resulting in enhanced therapeutic efficacy.

1065 A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.

1064 A cell-penetrating fluorescent marker is used to label cells in the metastatic tumour microenvironment, revealing a variety of cell types including parenchymal cells with lung stem-cell characteristics.

1063 Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation.

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