Cancer Biology

 
1103 High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
https://www.pnas.org/content/117/3/1666

1102 Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth.
https://advances.sciencemag.org/content/6/3/eaay2174

1101 Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.
https://stm.sciencemag.org/content/12/526/eaax7992

1100 Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.
https://stm.sciencemag.org/content/12/526/eaax9340

1099 Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
https://www.pnas.org/content/early/2019/12/26/1904022116

1098 HBO1 is required for the maintenance of leukaemia stem cells.
https://www.nature.com/articles/s41586-019-1835-6

1097 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/early/2019/12/30/science.aay5967

1096 Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer.
https://stm.sciencemag.org/content/12/524/eaax7533

1095 An artificial intelligence (AI) system performs as well as or better than radiologists at detecting breast cancer from mammograms, and using a combination of AI and human inputs could help to improve screening efficiency.
https://www.nature.com/articles/s41586-019-1799-6

1094 IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
https://rupress.org/jcb/article-abstract/219/2/e201903017/133547/IPO11-mediates-catenin-nuclear-import-in-a-subset?redirectedFrom=fulltext

1093 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.
https://www.pnas.org/content/116/52/26909

1092 Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
https://www.pnas.org/content/116/52/26580

1091 Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.
https://www.cell.com/cell/fulltext/S0092-8674(19)31269-3

1090 The GLASS Consortium studies the evolutionary trajectories of 222 patients with a diffuse glioma to aid in our understanding of tumour progression and treatment failure.
https://www.nature.com/articles/s41586-019-1775-1

1089 Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.
https://www.nature.com/articles/s41586-019-1763-5

1088 Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
https://science.sciencemag.org/content/366/6468/1029

1087 Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
https://www.nature.com/articles/s43018-019-0004-z

1086 Immunity to commensal papillomaviruses protects against skin cancer.
https://www.nature.com/articles/s41586-019-1719-9

1085 Mouse models of triple-negative breast cancer provide insights into how T follicular helper cell activation of B cells facilitates the effects of immune checkpoint inhibitors.
https://www.cell.com/cell/fulltext/S0092-8674(19)31178-X

1084 The Role of Non-coding RNAs in Oncology. (Review).
https://www.cell.com/cell/fulltext/S0092-8674(19)31167-5#%20

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