1082 Pan-cancer whole-genome analyses of metastatic solid tumours.
https://www.nature.com/articles/s41586-019-1689-y
1081 The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
https://www.nature.com/articles/s41586-019-1694-1
1080 Small cell lung cancer tumors are sensitive to DHODH inhibition, highlighting a potential treatment strategy for this disease.
https://stm.sciencemag.org/content/11/517/eaaw7852
1079 Some breast cancers harbor not one—but two—PIK3CA mutations, and this enhances their response to certain drugs.
https://science.sciencemag.org/content/366/6466/714
1078 The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.
https://cancerdiscovery.aacrjournals.org/content/early/2019/10/22/2159-8290.CD-19-1167
1077 n a mouse tumour model, immunotherapy-induced rejection of tumour cells requires presentation of both MHC class I and MHC class II antigens, which activate CD4+ and CD8+ T cells, respectively.
https://www.nature.com/articles/s41586-019-1671-8
1076 A highly recurrent A>C somatic mutation in U1 small nuclear RNA, which alters the splicing pattern of genes that include known drivers of cancer, is identified in several types of tumour.
https://www.nature.com/articles/s41586-019-1651-z
1075 Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.
https://www.cell.com/cell/fulltext/S0092-8674(19)31003-7
1074 PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.
https://www.nature.com/articles/s41590-019-0480-4
1073 Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.
https://stm.sciencemag.org/content/11/513/eaay2574
1072 Analyses of transcriptomes from patients with acute myeloid leukaemia identified frequently co-occurring mutations of IDH2 and SRSF2, which functional analyses showed to have distinct and coordinated leukaemogenic effects on the epigenome and RNA splicing.
https://www.nature.com/articles/s41586-019-1618-0
1071 Inducing and exploiting vulnerabilities for the treatment of liver cancer.
https://www.nature.com/articles/s41586-019-1607-3
1070 Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
https://www.pnas.org/content/116/41/20679
1069 α-Ketoglutarate links p53 to cell fate during tumour suppression.
https://www.nature.com/articles/s41586-019-1577-5
1068 E-cadherin is required for metastasis in multiple models of breast cancer.
https://www.nature.com/articles/s41586-019-1526-3
1067 Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases.
https://stm.sciencemag.org/content/11/509/eaaw8513
1066 Collagen-binding ability improves serum albumin as an anti-cancer drug carrier, resulting in enhanced therapeutic efficacy.
https://advances.sciencemag.org/content/5/8/eaaw6081
1065 A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.
https://advances.sciencemag.org/content/5/8/eaav6789
1064 A cell-penetrating fluorescent marker is used to label cells in the metastatic tumour microenvironment, revealing a variety of cell types including parenchymal cells with lung stem-cell characteristics.
https://www.nature.com/articles/s41586-019-1487-6
1063 Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30188-3
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