Orthopedics

Articles:
72 A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
https://stm.sciencemag.org/content/11/489/eaar4953

71 Biomaterials-aided mandibular reconstruction using in vivo bioreactors.
https://www.pnas.org/content/116/14/6954

70 Oral versus Intravenous Antibiotics for Bone and Joint Infection.
https://www.nejm.org/doi/full/10.1056/NEJMoa1710926

69 Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.
https://www.nature.com/articles/s41586-019-0874-3

68 Deep neural network improves fracture detection by clinicians.
http://www.pnas.org/content/115/45/11591

67 ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.
http://stm.sciencemag.org/content/10/458/eaar8426

66 Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30345-1/fulltext

65 Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32137-2/fulltext

64 Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep.
http://stm.sciencemag.org/content/10/423/eaam8828

63 C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis.
http://stke.sciencemag.org/content/10/509/eaan6282

62 Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1708322

61 Plasmodium products persist in the bone marrow and promote chronic bone loss.
http://immunology.sciencemag.org/content/2/12/eaam8093

60 In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism.
http://www.pnas.org/content/114/21/5419.abstract

59 In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs.
http://stm.sciencemag.org/content/9/390/eaal3128

58 RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis.
http://stm.sciencemag.org/content/9/374/eaai9338

57 Pharmacological rescue of diabetic skeletal stem cell niches.
http://stm.sciencemag.org/content/9/372/eaag2809

56 3D Porous Graphene by Low-Temperature Plasma Welding for Bone Implants.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201603146/full

55 Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats.
http://www.nature.com/nm/journal/v22/n10/abs/nm.4162.html

54 Romosozumab Treatment in Postmenopausal Women with Osteoporosis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1607948?query=featured_home

53 Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial.
http://stm.sciencemag.org/content/8/358/358ra127

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