| 16 In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous.
15 Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration.
14 Primary sensory areas of newborn mammals typically display input-dependent plasticity. Thomson and colleagues use a sensory prosthetic device in rats to show that adult rats can discriminate different infrared light signals, when the signals are routed to somatosensory cortex by electrical microstimulation.
13 An embedded system for aiding navigation of visually impaired persons.
12 Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
11 JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.
10 Reprogramming of adult rod photoreceptors prevents retinal degeneration.
9 Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
8 Repair of the degenerate retina by photoreceptor transplantation.
7 Goldman and colleagues report that the transcriptional repressor Insm1a is essential for retinal regeneration following injury in fish. Insm1a suppresses the expression of Ascl1a to promote Müller glial cells’ dedifferentiation at early stages of regeneration, and defines the regeneration zone by negatively regulating the expression of the heparin-binding EGF. It also halts the proliferation of retinal progenitors in the late stages of the process.
6 Retinal prosthetic strategy with the capacity to restore normal vision.
5 Restoration of vision after transplantation of photoreceptors.
4 Photovoltaic retinal prosthesis with high pixel density.
3 Age-Related Changes in the Retinal Pigment Epithelium (RPE).
2 Efficient Generation of Lens Progenitor Cells from Cataract Patient–Specific Induced Pluripotent Stem Cells.
1 Repeat administration of gene therapy to the contralateral retina of three congenitally blind patients was safe and resulted in improved vision. Bennett J. et al. (2012) Sci Transl Med. 4: p.120ra15