421 A highly soluble Sleeping Beauty transposase improves control of gene insertion.
https://www.nature.com/articles/s41587-019-0291-z
420 Using whole-genome sequencing data from 1,739 individuals, the GenomeAsia 100K Project catalogues genetic variation, population structure and disease associations to facilitate genetic studies in Asian populations and increase representation in genetics studies worldwide.
https://www.nature.com/articles/s41586-019-1793-z
419 A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.
https://www.cell.com/cell/fulltext/S0092-8674(19)31176-6
418 Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
https://science.sciencemag.org/content/366/6467/843
417 The degree to which a genome can tolerate mutations is inversely correlated with the fitness of a yeast strain.
https://science.sciencemag.org/content/366/6464/490
416 Search-and-replace genome editing without double-strand breaks or donor DNA.
https://www.nature.com/articles/s41586-019-1711-4
415 The piRNA Response to Retroviral Invasion of the Koala Genome.
https://www.cell.com/cell/fulltext/S0092-8674(19)31008-6
414 An Ancient Genome from the Indus Valley Civilization.
https://www.cell.com/cell/fulltext/S0092-8674(19)31078-5
413 Polymer nanocapsules, assembled around a ribonucleoprotein complex of Cas9 nuclease and a single-guide RNA, enable safe and efficient gene editing in vitro and in vivo.
https://www.nature.com/articles/s41565-019-0539-2
412 Acoustic reporter genes enable noninvasive ultrasound imaging of gene expression in mammalian cells.
https://science.sciencemag.org/content/365/6460/1469
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