Genetics

Articles:

422  Insights into human genetic variation and population history from 929 diverse genomes.
https://science.sciencemag.org/content/367/6484/eaay5012

421  A highly soluble Sleeping Beauty transposase improves control of gene insertion.
https://www.nature.com/articles/s41587-019-0291-z

420  Using whole-genome sequencing data from 1,739 individuals, the GenomeAsia 100K Project catalogues genetic variation, population structure and disease associations to facilitate genetic studies in Asian populations and increase representation in genetics studies worldwide.
https://www.nature.com/articles/s41586-019-1793-z

419  A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.
https://www.cell.com/cell/fulltext/S0092-8674(19)31176-6

418  Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
https://science.sciencemag.org/content/366/6467/843

417  The degree to which a genome can tolerate mutations is inversely correlated with the fitness of a yeast strain.
https://science.sciencemag.org/content/366/6464/490

416  Search-and-replace genome editing without double-strand breaks or donor DNA.
https://www.nature.com/articles/s41586-019-1711-4

415  The piRNA Response to Retroviral Invasion of the Koala Genome.
https://www.cell.com/cell/fulltext/S0092-8674(19)31008-6

414  An Ancient Genome from the Indus Valley Civilization.
https://www.cell.com/cell/fulltext/S0092-8674(19)31078-5

413  Polymer nanocapsules, assembled around a ribonucleoprotein complex of Cas9 nuclease and a single-guide RNA, enable safe and efficient gene editing in vitro and in vivo.
https://www.nature.com/articles/s41565-019-0539-2

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