Genetics

Articles:

401  A genome-wide polygenic score quantifies inherited susceptibility to obesity, integrating information from 2.1 million common genetic variants to identify adults at risk of severe obesity.
https://www.cell.com/cell/fulltext/S0092-8674(19)30290-9

400  Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
https://www.cell.com/cell/fulltext/S0092-8674(19)30345-9

399  Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.
https://www.nejm.org/doi/full/10.1056/NEJMoa1806627

398  In utero gene editing for monogenic lung disease.
https://stm.sciencemag.org/content/11/488/eaav8375

397  Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.
https://science.sciencemag.org/content/364/6437/289

396  Local Determinants of the Mutational Landscape of the Human Genome.
https://www.cell.com/cell/fulltext/S0092-8674(19)30234-X

395  Global Genetic Networks and the Genotype-to-Phenotype Relationship.
https://www.cell.com/cell/fulltext/S0092-8674(19)30096-0

394  A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila.
http://science.sciencemag.org/content/363/6426/509

393  Introns are mediators of cell response to starvation.
https://www.nature.com/articles/s41586-018-0859-7

392  A high-resolution human genetic map from whole genomes identifies patterns of recombination and de novo mutation.
http://science.sciencemag.org/content/363/6425/eaau1043

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