158 Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis.
http://www.pnas.org/content/113/15/3960.abstract
157 On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system.
http://science.sciencemag.org/content/352/6281/61
156 Precision multidimensional assay for high-throughput microRNA drug discovery.
http://www.nature.com/ncomms/2016/160216/ncomms10709/full/ncomms10709.html
155 Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.
http://www.nature.com/ncomms/2016/160216/ncomms10710/full/ncomms10710.html
154 Long-acting cocaine hydrolase for addiction therapy.
http://www.pnas.org/content/113/2/422.abstract
153 BRD4 is a novel therapeutic target for liver fibrosis.
http://www.pnas.org/content/112/51/15713.abstract
152 Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis.
http://stm.sciencemag.org/content/7/318/318ra201
151 Structural studies give insight into how a human sodium channel involved in pain perception can be selectively inhibited.
http://www.sciencemag.org/content/350/6267/aac5464.abstract
150 Yeast-based screening identifies the benzodiazepine drug lorazepam as a non-selective positive allosteric modulator of the G-protein-coupled receptor (GPCR) GPR68; homology modelling and molecular docking of 3.1 million molecules found a new compound, ‘ogerin’, as a potent GPR68 modulator, which suppressed recall in fear conditioning in wild-type mice, and the general method of combining physical and structure-based screening may lead to the discovery of selective ligands for other GPCRs.
http://www.nature.com/nature/journal/v527/n7579/full/nature15699.html
149 Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.
http://stm.sciencemag.org/content/7/314/314ra183
148 A compound that reverses the molecular cause of cataract formation improves eye lens transparency in mice.
http://www.sciencemag.org/content/350/6261/674.abstract
147 Helical antimicrobial polypeptides with radial amphiphilicity.
http://www.pnas.org/content/112/43/13155.abstract
146 Broad and efficient control of major foodborne pathogenic strains of Escherichia coli by mixtures of plant-produced colicins.
http://www.pnas.org/content/112/40/E5454
145 Idarucizumab for Dabigatran Reversal.
http://www.nejm.org/doi/full/10.1056/NEJMoa1502000
144 Complete biosynthesis of opioids in yeast.
http://www.sciencemag.org/content/early/2015/08/12/science.aac9373.abstract
143 Structure-based drug design identifies polythiophenes as antiprion compounds.
http://stm.sciencemag.org/content/7/299/299ra123
142 Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.
http://www.nature.com/ncomms/2015/150721/ncomms8719/full/ncomms8719.html
141 Poppies have fused into a single protein two enzymatic activities that are sequential in the metabolic pathway for making morphine.
http://www.sciencemag.org/content/349/6245/309.abstract
140 Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.
http://stke.sciencemag.org/content/8/382/ra63.abstract
139 Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.
http://stm.sciencemag.org/content/7/292/292ra98
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