Medical Science

Articles:
187 Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and abdominal pain (SECURE): a multicentre, randomised, parallel-arm, non-inferiority trial.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30941-9/fulltext

186 Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30419-2/fulltext

185 A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease.
https://www.nejm.org/doi/full/10.1056/NEJMoa1903212?query=featured_home

184 Association of Exposure to Artificial Light at Night While Sleeping With Risk of Obesity in Women.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2735446?guestAccessKey=5a107249-1470-48f6-a8fe-ffe680065c54&utm_source=For_The_Media

183 Taking Stock of Dietary Supplements' Harmful Effects on Children, Adolescents, and Young Adults.
https://www.sciencedirect.com/science/article/pii/S1054139X19301636?via%3Dihub

182 Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.
https://www.nature.com/articles/s41591-019-0414-6

181 Detecting middle ear fluid using smartphones.
https://stm.sciencemag.org/content/11/492/eaav1102

180 Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients.
https://www.nejm.org/doi/full/10.1056/NEJMoa1816885?query=featured_home

179 A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
https://www.pnas.org/content/early/2019/04/24/1901274116

178 A genome-wide polygenic score quantifies inherited susceptibility to obesity, integrating information from 2.1 million common genetic variants to identify adults at risk of severe obesity.
https://www.cell.com/cell/fulltext/S0092-8674(19)30290-9

177 In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.
http://stm.sciencemag.org/content/11/485/eaau7531

176 Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care.
http://science.sciencemag.org/content/363/6430/eaau0780

175 Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy.
https://www.pnas.org/content/116/9/3508

174 In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression.
https://www.pnas.org/content/116/9/3443

173 Identifying facial phenotypes of genetic disorders using deep learning.
https://www.nature.com/articles/s41591-018-0279-0

172 Roles of mucus adhesion and cohesion in cough clearance.
http://www.pnas.org/content/115/49/12501

171 Birth delivery mode alters perinatal cell death in the mouse brain.
http://www.pnas.org/content/115/46/11826

170 Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis.
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(18)30265-1/fulltext

169 Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
https://www.nejm.org/doi/full/10.1056/NEJMoa1800722?query=featured_home

168 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
https://www.nature.com/articles/s41588-018-0205-x#Abs1

167 Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.
https://www.nejm.org/doi/full/10.1056/NEJMoa1803583

166 Use of Deep Learning to Examine the Association of the Built Environment With Prevalence of Neighborhood Adult Obesity.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2698635

165 Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system.
http://www.pnas.org/content/115/33/8272

164 Targeted therapy in patients with PIK3CA-related overgrowth syndrome.
https://www.nature.com/articles/s41586-018-0217-9

163 A Randomized Trial of Early Endovenous Ablation in Venous Ulceration.
https://www.nejm.org/doi/full/10.1056/NEJMoa1801214

162 Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.
https://www.nejm.org/doi/full/10.1056/NEJMoa1706314

161 Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma.
https://www.nejm.org/doi/full/10.1056/NEJMoa1715274

160 Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
https://www.nejm.org/doi/full/10.1056/NEJMoa1713901

159 Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children.
https://www.nature.com/articles/s41598-018-24348-5

158 Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.
http://www.pnas.org/content/115/14/3686

157 Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.
http://www.nejm.org/doi/full/10.1056/NEJMoa1714257

156 A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops.
http://www.nejm.org/doi/full/10.1056/NEJMoa1717250?query=featured_home

155 Smartphone-based blood pressure monitoring via the oscillometric finger-pressing method.
http://stm.sciencemag.org/content/10/431/eaap8674

154 Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32160-8/fulltext

153 Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.
http://stm.sciencemag.org/content/10/427/eaam8604

152 Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing.
http://advances.sciencemag.org/content/4/1/eaap9004

151 Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett’s esophagus.
http://stm.sciencemag.org/content/10/424/eaao5848

150 Factoring in new gene therapy treatments for hemophilia A.
http://stm.sciencemag.org/content/10/423/eaar7511

149 Identification of acutely sick people and facial cues of sickness.
http://rspb.royalsocietypublishing.org/content/285/1870/20172430

148 Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
https://www.nature.com/articles/nature25164

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