72 A versatile platform reprograms botulinum neurotoxin proteases to selectively cleave proteins of biomedical interest in vitro and in neurons.
https://science.sciencemag.org/content/371/6531/803
71 Successful de novo design of transmembrane β-barrel proteins provides insight into the principles that guide their folding.
https://science.sciencemag.org/content/371/6531/eabc8182
70 DeepTFactor: A deep learning-based tool for the prediction of transcription factors.
https://www.pnas.org/content/118/2/e2021171118
69 The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease.
https://www.nature.com/articles/s41586-020-2681-2
68 Structures of the acetohydroxyacid synthase complexes of Saccharomyces cerevisiae and Arabidopsis thaliana provide insights into the biosynthesis of and feedback inhibition by branched-chain amino acids.
https://www.nature.com/articles/s41586-020-2514-3
67 ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.
https://stm.sciencemag.org/content/12/561/eaax3063
66 In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.
https://www.nature.com/articles/s41586-020-2494-3
65 An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.
https://www.pnas.org/content/117/31/18431
64 Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion.
https://www.pnas.org/content/117/27/15731
63 A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans.
https://advances.sciencemag.org/content/6/27/eaaw7824
62 The proteome landscape of the kingdoms of life.
https://www.nature.com/articles/s41586-020-2402-x
61 A compound that disassembles the circadian repressive super-complex can reset circadian phase and relieve jet lag in mice.
https://stm.sciencemag.org/content/12/542/eaba0769
60 A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.
https://www.nature.com/articles/s41586-020-2188-x
59 FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.
https://www.pnas.org/content/117/6/3135
58 The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.
https://www.nature.com/articles/s41586-019-1770-6
57 Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
https://science.sciencemag.org/content/366/6467/843
56 An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
https://stm.sciencemag.org/content/11/517/eaaw1131
55 mTORC1 senses nutrient sufficiency by recognizing conformational changes in its lysosomal anchor, heterodimeric Rag GTPase.
https://science.sciencemag.org/content/366/6464/468
54 How internal cavities destabilize a protein.
https://www.pnas.org/content/116/42/21031
53 A membrane protein, Shisa7, regulates trafficking, kinetics, and pharmacology of GABAA receptors.
https://science.sciencemag.org/content/366/6462/246
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