Proteome

Articles:

97 Rosetta design and machine learning generate protein fragments that assemble into a huge set of functional enzymes.
https://www.science.org/doi/10.1126/science.ade9434

96 Nanoscopy of single antifreeze proteins reveals that reversible ice binding is sufficient for ice recrystallization inhibition but not thermal hysteresis.
https://www.pnas.org/doi/10.1073/pnas.2212456120

95 Structure of monkeypox virus DNA polymerase holoenzyme.
https://www.science.org/doi/10.1126/science.ade6360

94 Bioengineered peptibodies as blockers of ion channels.
https://www.pnas.org/doi/10.1073/pnas.2212564119

93 Evolutionary-scale prediction of atomic level protein structure with a language model.
https://www.biorxiv.org/content/10.1101/2022.07.20.500902v2

92 Evolution and antiviral activity of a human protein of retroviral origin.
https://www.science.org/doi/10.1126/science.abq7871

91 Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature.
https://www.pnas.org/doi/10.1073/pnas.2208993119

90 The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery.
https://www.pnas.org/doi/10.1073/pnas.2207829119

89 A highly photostable and bright green fluorescent protein.
https://www.nature.com/articles/s41587-022-01278-2

88 Massively parallel, computationally guided design of a proenzyme.
https://www.pnas.org/doi/10.1073/pnas.2116097119

87 Amino acid sensor conserved from bacteria to humans.
https://www.pnas.org/doi/10.1073/pnas.2110415119

86 Multiple rereads of single proteins at single–amino acid resolution using nanopores.
https://www.science.org/doi/10.1126/science.abl4381

85 De novo protein design by deep network hallucination.
https://www.nature.com/articles/s41586-021-04184-w

84 An ancient antimicrobial protein co-opted by a fungal plant pathogen for in planta mycobiome manipulation.
https://www.pnas.org/content/118/49/e2110968118

83 Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
https://www.science.org/doi/10.1126/science.abe6723

82 Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202104581

81 Highly accurate protein structure prediction with AlphaFold.
https://www.nature.com/articles/s41586-021-03819-2

80 Highly accurate protein structure prediction for the human proteome.
https://www.nature.com/articles/s41586-021-03828-1

79 Protein structure modeling enables the rapid solution of protein structures and provides insights into function.
https://science.sciencemag.org/content/373/6557/871

78 Accurate prediction of protein structures and interactions using a three-track neural network.
https://science.sciencemag.org/content/early/2021/07/14/science.abj8754

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