34 Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.
https://www.pnas.org/content/116/4/1279
33 Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.
https://www.pnas.org/content/116/3/970
32 Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.
https://www.pnas.org/content/116/3/960
31 Computational design incorporating modular buried hydrogen networks produces highly orthogonal protein heterodimers.
https://www.nature.com/articles/s41586-018-0802-y
30 A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.
https://www.nature.com/articles/s41586-018-0781-z
29 Human cytomegalovirus US21 protein is a viroporin that modulates calcium homeostasis and protects cells against apoptosis.
https://www.pnas.org/content/115/52/E12370
28 Experimental accuracy in protein structure refinement via molecular dynamics simulations.
https://www.pnas.org/content/115/52/13276
27 Combined molecular dynamics and neural network method for predicting protein antifreeze activity.
https://www.pnas.org/content/115/52/13252
26 The Huluwa protein acts in the maternal Wnt/β-catenin pathway to establish the dorsal organizer of zebrafish and Xenopus embryos.
http://science.sciencemag.org/content/362/6417/eaat1045
25 De novo design of self-assembling helical protein filaments.
http://science.sciencemag.org/content/362/6415/705
24 ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
http://stm.sciencemag.org/content/10/462/eaam7486
23 Programmable protein circuits in living cells.
http://science.sciencemag.org/content/361/6408/1252
22 A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family.
http://advances.sciencemag.org/content/4/9/eaau4640
21 Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.
http://rspb.royalsocietypublishing.org/content/285/1886/20181656
20 Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking.
https://www.cell.com/cell/fulltext/S0092-8674(18)30958-9
19 SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
https://www.nature.com/articles/s41586-018-0437-z
18 A deep proteome analysis of human serum reveals the relationship between disease and genetics.
http://science.sciencemag.org/content/361/6404/769
17 A distinct abundant group of microbial rhodopsins discovered using functional metagenomics.
https://www.nature.com/articles/s41586-018-0225-9?utm_source=Nature_community&utm_medium=Community_sites&utm_content=BenJoh-Nature-MultipleJournals-Mi
16 Efficient encapsulation of proteins with random copolymers.
http://www.pnas.org/content/115/26/6578
15 Loss of esophageal SPINK7 unleashes protease activity, impairs barrier function, and induces proinflammatory responses.
http://stm.sciencemag.org/content/10/444/eaap9736
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