25  De novo design of self-assembling helical protein filaments.

24  ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.

23  Programmable protein circuits in living cells.

22  A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family.

21  Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.

20  Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking.

19  SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.

18  A deep proteome analysis of human serum reveals the relationship between disease and genetics.

17  A distinct abundant group of microbial rhodopsins discovered using functional metagenomics.

16  Efficient encapsulation of proteins with random copolymers.

15  Loss of esophageal SPINK7 unleashes protease activity, impairs barrier function, and induces proinflammatory responses.

14  A knock-in mutation in beclin 1 that increases autophagy in mice extends animal lifespan, improves healthspan, and also rescues early lethality in mice deficient in the anti-ageing protein klotho.

13  Xenoprotein engineering via synthetic libraries.

12  Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

11  The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.

10  A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.

9  Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.

8  A bound reaction intermediate sheds light on the mechanism of nitrogenase.

7  Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

6  Light-activated protein interaction with high spatial subcellular confinement.

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