45  Inhibition of natriuretic peptide receptor 1 reduces itch in mice.

44  Allosteric modulation of a human protein kinase with monobodies.

43  In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

42  SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

41  TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.

40  Critical role of spectrin in hearing development and deafness.

39  Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

38  The centrosome protein AKNA regulates neurogenesis via microtubule organization.

37  Microbiome-derived nitric oxide causes widespread post-translational modification of host proteins to regulate host functions and physiology.

36  Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

35  IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.

34  Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.

33  Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.

32  Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.

31  Computational design incorporating modular buried hydrogen networks produces highly orthogonal protein heterodimers.

30  A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.

29  Human cytomegalovirus US21 protein is a viroporin that modulates calcium homeostasis and protects cells against apoptosis.

28  Experimental accuracy in protein structure refinement via molecular dynamics simulations.

27  Combined molecular dynamics and neural network method for predicting protein antifreeze activity.

26  The Huluwa protein acts in the maternal Wnt/β-catenin pathway to establish the dorsal organizer of zebrafish and Xenopus embryos.

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