67  ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.

66  In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.

65  An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.

64  Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion.

63  A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans.

62  The proteome landscape of the kingdoms of life.

61  A compound that disassembles the circadian repressive super-complex can reset circadian phase and relieve jet lag in mice.

60  A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.

59  FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.

58  The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.

57  Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.

56  An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

55  mTORC1 senses nutrient sufficiency by recognizing conformational changes in its lysosomal anchor, heterodimeric Rag GTPase.

54  How internal cavities destabilize a protein.

53  A membrane protein, Shisa7, regulates trafficking, kinetics, and pharmacology of GABAA receptors.

52  YY1 transcriptionally represses TGFB1 in mice and may be a potential drug target for treating diabetic nephropathy.

51  A selective cell-penetrating scorpion toxin targets the irritant receptor, TRPA1, via a distinct biochemical mechanism from that used by irritants, allowing definition of a new mechanism of channel activation and interrogation of pathways of pain sensitization.

50  LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.

49  The plasmodium protein kinase PfCLK3 provides a specific protein kinase target for antimalarial development.

48  Compendium of 4,941 rumen metagenome-assembled genomes for rumen microbiome biology and enzyme discovery.

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