Proteome

Articles:
52  YY1 transcriptionally represses TGFB1 in mice and may be a potential drug target for treating diabetic nephropathy.
https://stm.sciencemag.org/content/11/510/eaaw2050

51  A selective cell-penetrating scorpion toxin targets the irritant receptor, TRPA1, via a distinct biochemical mechanism from that used by irritants, allowing definition of a new mechanism of channel activation and interrogation of pathways of pain sensitization.
https://www.cell.com/cell/fulltext/S0092-8674(19)30779-2

50  LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.
https://www.cell.com/cell/fulltext/S0092-8674(19)30786-X

49  The plasmodium protein kinase PfCLK3 provides a specific protein kinase target for antimalarial development.
https://science.sciencemag.org/content/365/6456/eaau1682

48  Compendium of 4,941 rumen metagenome-assembled genomes for rumen microbiome biology and enzyme discovery.
https://www.nature.com/articles/s41587-019-0202-3

47  Cholera toxin promotes pathogen acquisition of host-derived nutrients.
https://www.nature.com/articles/s41586-019-1453-3

46  A technique for the de novo design of switchable protein systems controlled by induced conformational change is demonstrated for three functional motifs, in vitro and in yeast and mammalian cells.
https://www.nature.com/articles/s41586-019-1432-8

45  Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
https://stm.sciencemag.org/content/11/500/eaav5464

44  Allosteric modulation of a human protein kinase with monobodies.
https://www.pnas.org/content/116/28/13937

43  In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.
https://www.pnas.org/content/116/23/11490

42  SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
https://www.cell.com/cell/fulltext/S0092-8674(19)30344-7

41  TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.
https://www.pnas.org/content/116/17/8155

40  Critical role of spectrin in hearing development and deafness.
https://advances.sciencemag.org/content/5/4/eaav7803

39  Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
https://www.nature.com/articles/s41586-019-0993-x

38  The centrosome protein AKNA regulates neurogenesis via microtubule organization.
https://www.nature.com/articles/s41586-019-0962-4

37  Microbiome-derived nitric oxide causes widespread post-translational modification of host proteins to regulate host functions and physiology.
https://www.cell.com/cell/fulltext/S0092-8674(19)30100-X

36  Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
https://www.pnas.org/content/116/7/2545

35  IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.
https://www.nature.com/articles/s41598-018-38274-z

34  Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.
https://www.pnas.org/content/116/4/1279

33  Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.
https://www.pnas.org/content/116/3/970

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