Proteome

Articles:
88  Massively parallel, computationally guided design of a proenzyme.
https://www.pnas.org/doi/10.1073/pnas.2116097119

87  Amino acid sensor conserved from bacteria to humans.
https://www.pnas.org/doi/10.1073/pnas.2110415119

86  Multiple rereads of single proteins at single–amino acid resolution using nanopores.
https://www.science.org/doi/10.1126/science.abl4381

85  De novo protein design by deep network hallucination.
https://www.nature.com/articles/s41586-021-04184-w

84  An ancient antimicrobial protein co-opted by a fungal plant pathogen for in planta mycobiome manipulation.
https://www.pnas.org/content/118/49/e2110968118

83  Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
https://www.science.org/doi/10.1126/science.abe6723

82  Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202104581

81  Highly accurate protein structure prediction with AlphaFold.
https://www.nature.com/articles/s41586-021-03819-2

80  Highly accurate protein structure prediction for the human proteome.
https://www.nature.com/articles/s41586-021-03828-1

79  Protein structure modeling enables the rapid solution of protein structures and provides insights into function.
https://science.sciencemag.org/content/373/6557/871

78  Accurate prediction of protein structures and interactions using a three-track neural network.
https://science.sciencemag.org/content/early/2021/07/14/science.abj8754

77  Interferon-induced APOL3 is a detergent-like protein that kills cytosolic pathogens to protect human cells against infection.
https://science.sciencemag.org/content/373/6552/eabf8113

76  Data storage using peptide sequences.
https://www.nature.com/articles/s41467-021-24496-9

75  Computationally designed proteins assemble antibodies into precise and potent nanostructures.
https://science.sciencemag.org/content/372/6537/eabd9994

74  The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.
https://www.pnas.org/content/118/11/e2019251118

73  The intracellular environment affects protein–protein interactions.
https://www.pnas.org/content/118/11/e2019918118

72  A versatile platform reprograms botulinum neurotoxin proteases to selectively cleave proteins of biomedical interest in vitro and in neurons.
https://science.sciencemag.org/content/371/6531/803

71  Successful de novo design of transmembrane β-barrel proteins provides insight into the principles that guide their folding.
https://science.sciencemag.org/content/371/6531/eabc8182

70  DeepTFactor: A deep learning-based tool for the prediction of transcription factors.
https://www.pnas.org/content/118/2/e2021171118

69  The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease.
https://www.nature.com/articles/s41586-020-2681-2

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