59  FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.

58  The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.

57  Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.

56  An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

55  mTORC1 senses nutrient sufficiency by recognizing conformational changes in its lysosomal anchor, heterodimeric Rag GTPase.

54  How internal cavities destabilize a protein.

53  A membrane protein, Shisa7, regulates trafficking, kinetics, and pharmacology of GABAA receptors.

52  YY1 transcriptionally represses TGFB1 in mice and may be a potential drug target for treating diabetic nephropathy.

51  A selective cell-penetrating scorpion toxin targets the irritant receptor, TRPA1, via a distinct biochemical mechanism from that used by irritants, allowing definition of a new mechanism of channel activation and interrogation of pathways of pain sensitization.

50  LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.

49  The plasmodium protein kinase PfCLK3 provides a specific protein kinase target for antimalarial development.

48  Compendium of 4,941 rumen metagenome-assembled genomes for rumen microbiome biology and enzyme discovery.

47  Cholera toxin promotes pathogen acquisition of host-derived nutrients.

46  A technique for the de novo design of switchable protein systems controlled by induced conformational change is demonstrated for three functional motifs, in vitro and in yeast and mammalian cells.

45  Inhibition of natriuretic peptide receptor 1 reduces itch in mice.

44  Allosteric modulation of a human protein kinase with monobodies.

43  In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

42  SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

41  TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.

40  Critical role of spectrin in hearing development and deafness.

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