45 Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
https://stm.sciencemag.org/content/11/500/eaav5464
44 Allosteric modulation of a human protein kinase with monobodies.
https://www.pnas.org/content/116/28/13937
43 In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.
https://www.pnas.org/content/116/23/11490
42 SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
https://www.cell.com/cell/fulltext/S0092-8674(19)30344-7
41 TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.
https://www.pnas.org/content/116/17/8155
40 Critical role of spectrin in hearing development and deafness.
https://advances.sciencemag.org/content/5/4/eaav7803
39 Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
https://www.nature.com/articles/s41586-019-0993-x
38 The centrosome protein AKNA regulates neurogenesis via microtubule organization.
https://www.nature.com/articles/s41586-019-0962-4
37 Microbiome-derived nitric oxide causes widespread post-translational modification of host proteins to regulate host functions and physiology.
https://www.cell.com/cell/fulltext/S0092-8674(19)30100-X
36 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
https://www.pnas.org/content/116/7/2545
35 IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.
https://www.nature.com/articles/s41598-018-38274-z
34 Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.
https://www.pnas.org/content/116/4/1279
33 Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases.
https://www.pnas.org/content/116/3/970
32 Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.
https://www.pnas.org/content/116/3/960
31 Computational design incorporating modular buried hydrogen networks produces highly orthogonal protein heterodimers.
https://www.nature.com/articles/s41586-018-0802-y
30 A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.
https://www.nature.com/articles/s41586-018-0781-z
29 Human cytomegalovirus US21 protein is a viroporin that modulates calcium homeostasis and protects cells against apoptosis.
https://www.pnas.org/content/115/52/E12370
28 Experimental accuracy in protein structure refinement via molecular dynamics simulations.
https://www.pnas.org/content/115/52/13276
27 Combined molecular dynamics and neural network method for predicting protein antifreeze activity.
https://www.pnas.org/content/115/52/13252
26 The Huluwa protein acts in the maternal Wnt/β-catenin pathway to establish the dorsal organizer of zebrafish and Xenopus embryos.
http://science.sciencemag.org/content/362/6417/eaat1045
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