233 A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation in a rat model of arthritis without steroid toxicity.
https://stm.sciencemag.org/content/12/533/eaay1041
232 AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.
https://www.pnas.org/content/117/9/4921
231 JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.
https://stm.sciencemag.org/content/12/530/eaay4447
230 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.
https://www.pnas.org/content/116/52/26909
229 Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
https://www.nature.com/articles/s41586-019-1665-6
228 A new antibiotic selectively kills Gram-negative pathogens.
https://www.nature.com/articles/s41586-019-1791-1
227 A multistep biocatalytic cascade is applied to the synthesis of the experimental HIV drug islatravir.
https://science.sciencemag.org/content/366/6470/1255
226 A small molecule protects mitochondrial integrity by inhibiting mTOR activity.
https://www.pnas.org/content/116/46/23332
225 A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities.
https://stm.sciencemag.org/content/11/517/eaax5516
224 Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.
https://www.nature.com/articles/s41587-019-0222-z
223 Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics.
https://www.nature.com/articles/s41587-019-0241-9
222 Clinical benefit was observed in 34% of a cohort of 215 patients with cancer who received treatment with anticancer drugs outside of their approved label, in the Drug Rediscovery protocol trial.
https://www.nature.com/articles/s41586-019-1600-x
221 Repurposing dasatinib for diffuse large B cell lymphoma.
https://www.pnas.org/content/116/34/16981
220 Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes.
https://www.nature.com/articles/s41586-019-1315-z
219 Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease.
https://www.nejm.org/doi/full/10.1056/NEJMoa1903076?query=featured_home
218 1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom.
https://www.pnas.org/content/116/26/12642
217 Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.
https://stm.sciencemag.org/content/11/497/eaav1386
216 Targeting RIPK1 for the treatment of human diseases.
https://www.pnas.org/content/116/20/9714
215 Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote.
https://www.nature.com/articles/s41467-019-09681-1
214 Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30067-1
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