214 Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

213 Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

212 Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.

211 Pharmaceutical diversification via palladium oxidative addition complexes.

210 AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

209 Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist.

208 An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse.

207 On-demand manufacturing of clinical-quality biopharmaceuticals.

206 Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.

205 Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

204 Optimized arylomycins are a new class of Gram-negative antibiotics.

203 A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.

202 Suppression of Staphylococcus aureus virulence by a small-molecule compound.

201 Species-specific activity of antibacterial drug combinations

200 A new class of synthetic retinoid antibiotics effective against bacterial persisters.

199 Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.

198 The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.

197 A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

196 Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.

195 Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

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