214 Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30067-1
213 Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
https://www.pnas.org/content/116/8/3072
212 Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.
http://advances.sciencemag.org/content/5/2/eaav5590
211 Pharmaceutical diversification via palladium oxidative addition complexes.
http://science.sciencemag.org/content/363/6425/405
210 AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
https://www.pnas.org/content/116/4/1414
209 Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist.
http://www.pnas.org/content/115/45/11597
208 An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse.
http://advances.sciencemag.org/content/4/10/eaat4751
207 On-demand manufacturing of clinical-quality biopharmaceuticals.
https://www.nature.com/articles/nbt.4262
206 Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
http://www.pnas.org/content/115/40/10124
205 Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.
http://stm.sciencemag.org/content/10/460/eaat7520
204 Optimized arylomycins are a new class of Gram-negative antibiotics.
https://www.nature.com/articles/s41586-018-0483-6
203 A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
http://stm.sciencemag.org/content/10/456/eaar3483
202 Suppression of Staphylococcus aureus virulence by a small-molecule compound.
http://www.pnas.org/content/115/31/8003
201 Species-specific activity of antibacterial drug combinations
https://www.nature.com/articles/s41586-018-0278-9
200 A new class of synthetic retinoid antibiotics effective against bacterial persisters.
https://www.nature.com/articles/nature26157
199 Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.
http://science.sciencemag.org/content/359/6373/314
198 The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.
http://stm.sciencemag.org/content/10/423/eaan4044
197 A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
http://science.sciencemag.org/content/358/6368/1332
196 Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
http://www.cell.com/cell/fulltext/S0092-8674(17)31257-6
195 Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
https://www.nature.com/nature/journal/v550/n7677/full/nature24451.html
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