272 Tirzepatide Once Weekly for the Treatment of Obesity.
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038?query=featured_home
271 Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.
https://www.science.org/doi/10.1126/sciadv.abm2055
270 Computer-designed repurposing of chemical wastes into drugs.
https://www.nature.com/articles/s41586-022-04503-9
269 Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.
https://www.acpjournals.org/doi/10.7326/M21-4389
268 Two Phase 3 Trials of Baricitinib for Alopecia Areata.
https://www.nejm.org/doi/full/10.1056/NEJMoa2110343?query=featured_home
267 Bacterioboat is a good bacteria-based oral drug delivery tool that enhances drug efficacy and potency and makes drugs safer.
https://www.science.org/doi/10.1126/sciadv.abh1419
266 Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria.
https://www.science.org/doi/10.1126/scitranslmed.abj0716
265 An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
https://www.science.org/doi/10.1126/science.abl4784
264 Rational design of a new antibiotic class for drug-resistant infections.
https://www.nature.com/articles/s41586-021-03899-0
263 A repurposing screen identifies the orally available drug masitinib as able to inhibit virus replication in mouse-based models of COVID-19.
https://science.sciencemag.org/content/373/6557/931
262 The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
https://stm.sciencemag.org/content/13/603/eabg6013
261 Inhalable nanocatchers for SARS-CoV-2 inhibition.
https://www.pnas.org/content/118/29/e2102957118
260 The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase.
https://www.nature.com/articles/s41586-021-03455-w
259 Neutralization of endothelial lipase with a monoclonal antibody raises functional HDL in both nonhuman primates and in healthy humans.
https://stm.sciencemag.org/content/13/590/eabb0602
258 Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.
https://www.nature.com/articles/s41591-020-01224-2
257 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
https://www.pnas.org/content/118/13/e2015433118
256 The clinically approved drugs ticagrelor and oseltamivir fortify a pathway of platelet-mediated immunity to clear staphylococcal bacteremia in mice.
https://stm.sciencemag.org/content/13/586/eabd6737
255 Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
https://www.pnas.org/content/118/10/e2016265118
254 Bepridil is potent against SARS-CoV-2 in vitro.
https://www.pnas.org/content/118/10/e2012201118
253 Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome.
https://www.pnas.org/content/117/29/17389
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