54 Saccharomyces cerevisiae is engineered to produce high concentrations of artemisinic acid, a precursor of the artemisinin used in combination therapies for malaria treatment; an efficient and practical chemical process to convert artemisinic acid to artemisinin is also developed.
http://www.nature.com/nature/journal/v496/n7446/full/nature12051.html
53 Enantioselective Synthesis of Pactamycin, a Complex Antitumor Antibiotic.
http://www.sciencemag.org/content/340/6129/180.abstract
52 A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase.
http://www.cell.com/chemistry-biology/abstract/S1074-5521(13)00035-5
51 Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase.
http://www.cell.com/chemistry-biology/abstract/S1074-5521(13)00038-0
50 Identification of a Broad-Spectrum Inhibitor of Viral RNA Synthesis: Validation of a Prototype Virus-Based Approach.
http://www.cell.com/chemistry-biology/abstract/S1074-5521(13)00081-1
49 Quinolone-3-Diarylethers: A New Class of Antimalarial Drug.
http://stm.sciencemag.org/content/5/177/177ra37
48 Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
http://www.nature.com/ncomms/journal/v4/n2/full/ncomms2506.html
47 Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication.
http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2012.264.html
46 ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
http://www.nature.com/nature/journal/v494/n7435/full/nature11774.html
45 Antibacterial drug leads targeting isoprenoid biosynthesis.
http://www.pnas.org/content/110/1/123.abstract
44 Automated design of ligands to polypharmacological profiles.
http://www.nature.com/nature/journal/v492/n7428/full/nature11691.html
43 Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex.
http://stm.sciencemag.org/content/4/162/162ra153.abstract
42 Lithographically Encoded Polymer Microtaggant Using High-Capacity and Error-Correctable QR Code for Anti-Counterfeiting of Drugs.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201201486/abstract
41 CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.
http://www.nature.com/ncomms/journal/v3/n10/full/ncomms2149.html
40 PEG-b-PtBA-b-PHEMA well-defined amphiphilic triblock copolymer: Synthesis, self-assembly, and application in drug delivery.
http://onlinelibrary.wiley.com/doi/10.1002/pola.26273/abstract
39 Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.
http://www.pnas.org/content/109/39/15930.abstract
38 A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine.
http://www.sciencemag.org/content/336/6089/1704.abstract
37 Large-scale prediction and testing of drug activity on side-effect targets.
http://www.nature.com/nature/journal/v486/n7403/full/nature11159.html
36 Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
http://www.pnas.org/content/109/24/9629.abstract
35 Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.
http://www.pnas.org/content/109/24/9623.abstract
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