Pharmacology

Articles:

180 Systemic delivery of factor IX messenger RNA for protein replacement therapy.
http://www.pnas.org/content/114/10/E1941.abstract

179 CD6 as a potential target for treating multiple sclerosis.
http://www.pnas.org/content/114/10/2687.abstract

178 A nontoxic pain killer designed by modeling of pathological receptor conformations.
http://science.sciencemag.org/content/355/6328/966

177 Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy.
http://jem.rupress.org/content/214/2/547

176 Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library.
http://www.pnas.org/content/114/7/1708.abstract

175 Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.
http://stm.sciencemag.org/content/9/376/eaah5645

174 Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function.
http://stm.sciencemag.org/content/9/376/eaaf6094

173 A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
http://www.nejm.org/doi/full/10.1056/NEJMoa1609243

172 SC83288 is a clinical development candidate for the treatment of severe malaria.
http://www.nature.com/articles/ncomms14193

171 6’-Sialyllactose conjugated to polyamidoamine dendrimers at a well-defined valency and spacing can circumvent drug resistance and inhibit influenza A viruses.
http://www.nature.com/nnano/journal/v12/n1/abs/nnano.2016.181.html

170 Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
http://stm.sciencemag.org/content/8/368/368ra173

169 Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
http://www.nature.com/nature/journal/v538/n7625/full/nature19804.html

168 Purinergic receptors in the carotid body as a new drug target for controlling hypertension.
http://www.nature.com/nm/journal/v22/n10/abs/nm.4173.html

167 Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO).
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31324-1/fulltext

166 Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA).
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31322-8/fulltext

165 Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
http://www.nature.com/articles/ncomms12777

164 Treatment of otitis media by transtympanic delivery of antibiotics.
http://stm.sciencemag.org/content/8/356/356ra120

163 A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.
http://www.nature.com/nature/journal/v537/n7619/full/nature19339.html

162 Like citrate, the molecule hydroxycitrate is shown to inhibit growth of the crystal that is the principal component of kidney stones, suggesting that hydroxycitrate could be another treatment for kidney stone disease.
http://www.nature.com/nature/journal/v536/n7617/full/nature19062.html

161 Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.
http://www.nature.com/ncomms/2016/160801/ncomms12348/full/ncomms12348.html

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