Pharmacology

Articles:

185 A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
https://www.nature.com/nature/journal/v546/n7658/full/nature22337.html

184 Predictive compound accumulation rules yield a broad-spectrum antibiotic.
https://www.nature.com/nature/journal/v545/n7654/full/nature22308.html

183 Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab.
http://www.nejm.org/doi/full/10.1056/NEJMoa1614062

182 Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
http://www.pnas.org/content/114/14/3750.abstract

181 The druggable genome and support for target identification and validation in drug development.
http://stm.sciencemag.org/content/9/383/eaag1166

180 Systemic delivery of factor IX messenger RNA for protein replacement therapy.
http://www.pnas.org/content/114/10/E1941.abstract

179 CD6 as a potential target for treating multiple sclerosis.
http://www.pnas.org/content/114/10/2687.abstract

178 A nontoxic pain killer designed by modeling of pathological receptor conformations.
http://science.sciencemag.org/content/355/6328/966

177 Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy.
http://jem.rupress.org/content/214/2/547

176 Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library.
http://www.pnas.org/content/114/7/1708.abstract

175 Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors.
http://stm.sciencemag.org/content/9/376/eaah5645

174 Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function.
http://stm.sciencemag.org/content/9/376/eaaf6094

173 A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
http://www.nejm.org/doi/full/10.1056/NEJMoa1609243

172 SC83288 is a clinical development candidate for the treatment of severe malaria.
http://www.nature.com/articles/ncomms14193

171 6’-Sialyllactose conjugated to polyamidoamine dendrimers at a well-defined valency and spacing can circumvent drug resistance and inhibit influenza A viruses.
http://www.nature.com/nnano/journal/v12/n1/abs/nnano.2016.181.html

170 Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
http://stm.sciencemag.org/content/8/368/368ra173

169 Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
http://www.nature.com/nature/journal/v538/n7625/full/nature19804.html

168 Purinergic receptors in the carotid body as a new drug target for controlling hypertension.
http://www.nature.com/nm/journal/v22/n10/abs/nm.4173.html

167 Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO).
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31324-1/fulltext

166 Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA).
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31322-8/fulltext

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