233 A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation in a rat model of arthritis without steroid toxicity.

232 AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.

231 JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

230 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.

229 Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

228 A new antibiotic selectively kills Gram-negative pathogens.

227 A multistep biocatalytic cascade is applied to the synthesis of the experimental HIV drug islatravir.

226 A small molecule protects mitochondrial integrity by inhibiting mTOR activity.

225 A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities.

224 Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

223 Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics.

222 Clinical benefit was observed in 34% of a cohort of 215 patients with cancer who received treatment with anticancer drugs outside of their approved label, in the Drug Rediscovery protocol trial.

221 Repurposing dasatinib for diffuse large B cell lymphoma.

220 Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes.

219 Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease.

218 1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom.

217 Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.

216 Targeting RIPK1 for the treatment of human diseases.

215 Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote.

214 Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

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