Pharmacology

Articles:

242 Monomeric insulin stabilized with polymeric excipient exhibits increased stability and faster pharmacokinetics than current rapid-acting insulins.
https://stm.sciencemag.org/content/12/550/eaba6676

241 Galidesivir, a broad-spectrum direct-acting adenosine analog antiviral drug, abrogates viremia in rhesus macaques infected with Zika virus.
https://stm.sciencemag.org/content/12/547/eaau9135

240 Structures of mycobacterial glycosyltransferases define a binding site for an anti-tuberculosis drug.
https://science.sciencemag.org/content/368/6496/1211

239 An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells.
https://stm.sciencemag.org/content/12/546/eaaz2254

238 Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.
https://stm.sciencemag.org/content/12/542/eaay8314

237 Elesclomol therapy stops the progression of neurodegeneration and improves survival in a mouse model of Menkes disease.
https://science.sciencemag.org/content/368/6491/620

236 An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
https://stm.sciencemag.org/content/12/541/eabb5883

235 An open-source drug discovery platform enables ultra-large virtual screens.
https://www.nature.com/articles/s41586-020-2117-z

234 A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.
https://www.pnas.org/content/117/16/9082

233 A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation in a rat model of arthritis without steroid toxicity.
https://stm.sciencemag.org/content/12/533/eaay1041

232 AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.
https://www.pnas.org/content/117/9/4921

231 JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.
https://stm.sciencemag.org/content/12/530/eaay4447

230 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.
https://www.pnas.org/content/116/52/26909

229 Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
https://www.nature.com/articles/s41586-019-1665-6

228 A new antibiotic selectively kills Gram-negative pathogens.
https://www.nature.com/articles/s41586-019-1791-1

227 A multistep biocatalytic cascade is applied to the synthesis of the experimental HIV drug islatravir.
https://science.sciencemag.org/content/366/6470/1255

226 A small molecule protects mitochondrial integrity by inhibiting mTOR activity.
https://www.pnas.org/content/116/46/23332

225 A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities.
https://stm.sciencemag.org/content/11/517/eaax5516

224 Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.
https://www.nature.com/articles/s41587-019-0222-z

223 Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics.
https://www.nature.com/articles/s41587-019-0241-9

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