253 Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome.
https://www.pnas.org/content/117/29/17389
252 Targeting cartilage EGFR pathway for osteoarthritis treatment
https://stm.sciencemag.org/content/13/576/eabb3946
251 Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties.
https://www.pnas.org/content/117/43/26936
250 A deltamethrin crystal polymorph for more effective malaria control.
https://www.pnas.org/content/117/43/26633
249 Designed miniproteins bind tightly to the SARS-CoV-2 spike protein and prevent binding to the host cell receptor.
https://science.sciencemag.org/content/370/6515/426
248 Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
https://www.nature.com/articles/s41586-020-2577-1
247 Modular synthesis and structural biology are used to design and characterize group A streptogramin antibiotics, one of which has activity against streptogramin-resistant strains and demonstrates efficacy in a mouse model of bacterial infection.
https://www.nature.com/articles/s41586-020-2761-3
246 Biosynthesis of medicinal tropane alkaloids in yeast.
https://www.nature.com/articles/s41586-020-2650-9
245 Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
https://www.nature.com/articles/s41586-020-2423-5
244 Discovery and engineering of colchicine alkaloid biosynthesis.
https://www.nature.com/articles/s41586-020-2546-8
243 Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics.
https://www.cell.com/cell/fulltext/S0092-8674(20)30623-1
242 Monomeric insulin stabilized with polymeric excipient exhibits increased stability and faster pharmacokinetics than current rapid-acting insulins.
https://stm.sciencemag.org/content/12/550/eaba6676
241 Galidesivir, a broad-spectrum direct-acting adenosine analog antiviral drug, abrogates viremia in rhesus macaques infected with Zika virus.
https://stm.sciencemag.org/content/12/547/eaau9135
240 Structures of mycobacterial glycosyltransferases define a binding site for an anti-tuberculosis drug.
https://science.sciencemag.org/content/368/6496/1211
239 An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells.
https://stm.sciencemag.org/content/12/546/eaaz2254
238 Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.
https://stm.sciencemag.org/content/12/542/eaay8314
237 Elesclomol therapy stops the progression of neurodegeneration and improves survival in a mouse model of Menkes disease.
https://science.sciencemag.org/content/368/6491/620
236 An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
https://stm.sciencemag.org/content/12/541/eabb5883
235 An open-source drug discovery platform enables ultra-large virtual screens.
https://www.nature.com/articles/s41586-020-2117-z
234 A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.
https://www.pnas.org/content/117/16/9082
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