224 Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

223 Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics.

222 Clinical benefit was observed in 34% of a cohort of 215 patients with cancer who received treatment with anticancer drugs outside of their approved label, in the Drug Rediscovery protocol trial.

221 Repurposing dasatinib for diffuse large B cell lymphoma.

220 Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes.

219 Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease.

218 1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom.

217 Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.

216 Targeting RIPK1 for the treatment of human diseases.

215 Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote.

214 Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

213 Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

212 Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.

211 Pharmaceutical diversification via palladium oxidative addition complexes.

210 AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

209 Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist.

208 An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse.

207 On-demand manufacturing of clinical-quality biopharmaceuticals.

206 Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.

205 Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

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