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Pharmacology

Pharmacology

Articles:

286 Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus
https://www.science.org/doi/10.1126/science.adk6176

285 Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics
https://www.science.org/doi/10.1126/science.adk7368

284 Discovery of a structural class of antibiotics with explainable deep learning
https://www.nature.com/articles/s41586-023-06887-8

283 Boosting systemic absorption of peptides with a bioinspired buccal-stretching patch.
https://www.science.org/doi/10.1126/scitranslmed.abq1887

282 An antibiotic from an uncultured bacterium binds to an immutable target.
https://www.cell.com/cell/fulltext/S0092-8674(23)00853-X

281 Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate.
https://www.science.org/doi/10.1126/scitranslmed.abh3489

280 Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.
https://www.pnas.org/doi/10.1073/pnas.2217734120

279 A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.
https://www.pnas.org/doi/10.1073/pnas.2209924120

278 Terpene biosynthesis in marine sponge animals.
https://www.pnas.org/doi/10.1073/pnas.2220934120

277 Metformin acts in the gut and induces gut-liver crosstalk.
https://www.pnas.org/doi/10.1073/pnas.2211933120

276 Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
https://www.science.org/doi/10.1126/sciadv.abq5925

275 Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
https://www.nature.com/articles/s41587-022-01334-x

274 A small-molecule compound may help in the development of rapidly acting antidepressants by regulating the firing of serotonergic neurons.
https://www.science.org/doi/10.1126/science.abo3566

273 A high-throughput virtual screen followed by experimental testing generates therapeutic leads for non-opioid pain killers.
https://www.science.org/doi/10.1126/science.abn7065

272 Tirzepatide Once Weekly for the Treatment of Obesity.
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038?query=featured_home

271 Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.
https://www.science.org/doi/10.1126/sciadv.abm2055

270 Computer-designed repurposing of chemical wastes into drugs.
https://www.nature.com/articles/s41586-022-04503-9

269 Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.
https://www.acpjournals.org/doi/10.7326/M21-4389

268 Two Phase 3 Trials of Baricitinib for Alopecia Areata.
https://www.nejm.org/doi/full/10.1056/NEJMoa2110343?query=featured_home

267 Bacterioboat is a good bacteria-based oral drug delivery tool that enhances drug efficacy and potency and makes drugs safer.
https://www.science.org/doi/10.1126/sciadv.abh1419

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