249 Genetic, pharmacological and metabolomics experiments reveal that the malate–aspartate shuttle and mitochondrial citrate export support the differentiation of mouse T helper 1 cells, whereas succinate dehydrogenase enforces their terminal effector function.
https://www.nature.com/articles/s41586-019-1311-3
248 De novo design of symmetric ferredoxins that shuttle electrons in vivo.
https://www.pnas.org/content/116/29/14557
247 PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.
https://www.pnas.org/content/116/27/13394
246 Microbial production of methyl anthranilate, a grape flavor compound.
https://www.pnas.org/content/116/22/10749
245 Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia.
https://www.pnas.org/content/116/22/10744
244 Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides.
https://www.pnas.org/content/116/22/10658
243 Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.
https://www.nature.com/articles/s41591-019-0423-5
242 Constrained sialic acid donors enable selective synthesis of α-glycosides.
https://science.sciencemag.org/content/364/6441/677
241 Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins.
https://science.sciencemag.org/content/364/6441/674
240 The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.
https://stm.sciencemag.org/content/11/489/eaav0120
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