249  Genetic, pharmacological and metabolomics experiments reveal that the malate–aspartate shuttle and mitochondrial citrate export support the differentiation of mouse T helper 1 cells, whereas succinate dehydrogenase enforces their terminal effector function.

248  De novo design of symmetric ferredoxins that shuttle electrons in vivo.

247  PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.

246  Microbial production of methyl anthranilate, a grape flavor compound.

245  Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia.

244  Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides.

243  Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.

242  Constrained sialic acid donors enable selective synthesis of α-glycosides.

241  Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins.

240  The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.

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