240 An oral macrolide drug targeting the bacterial endosymbiont, Wolbachia, shows efficacy against filarial nematodes in preclinical animal models.
http://stm.sciencemag.org/content/11/483/eaau2086
239 A retrievable device, compatible with nasogastric tube administration, releases grams of drug over weeks while residing in the stomach.
http://stm.sciencemag.org/content/11/483/eaau6267
238 Omadacycline for Community-Acquired Bacterial Pneumonia.
https://www.nejm.org/doi/full/10.1056/NEJMoa1800201
237 Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers.
https://www.nejm.org/doi/full/10.1056/NEJMoa1716771
236 HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control.
https://www.pnas.org/content/116/3/944
235 Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea.
https://www.nejm.org/doi/full/10.1056/NEJMoa1706988
234 A Trial of a Triple-Drug Treatment for Lymphatic Filariasis.
https://www.nejm.org/doi/full/10.1056/NEJMoa1706854
233 Epidemiology of the silent polio outbreak in Rahat, Israel, based on modeling of environmental surveillance data.
http://www.pnas.org/content/115/45/E10625
232 Seasonal flu epidemics are more diffuse in larger cities and more intense in smaller cities, where climate has a stronger influence on transmission.
http://science.sciencemag.org/content/362/6410/75
231 The temporal relationship between onchocerciasis and epilepsy: a population-based cohort study.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30425-0/fulltext
230 Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.
http://stm.sciencemag.org/content/10/460/eaat7520
229 Semisynthetic sensor proteins enable metabolic assays at the point of care.
http://science.sciencemag.org/content/361/6407/1122
228 Optimized arylomycins are a new class of Gram-negative antibiotics.
https://www.nature.com/articles/s41586-018-0483-6
227 Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30349-9/fulltext
226 The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30348-7/fulltext
225 Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30285-8/fulltext
224 Bacterial Factors That Predict Relapse after Tuberculosis Therapy.
https://www.nejm.org/doi/full/10.1056/NEJMoa1715849
223 Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.
https://www.nejm.org/doi/full/10.1056/NEJMoa1716197?query=featured_home
222 MinION genomic and case data on a recent yellow fever epidemic indicate that most infections occurred during visits to forest regions.
http://science.sciencemag.org/content/361/6405/894
221 Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates.
http://stm.sciencemag.org/content/10/449/eaaq1564
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