Oncology

Articles:
252 Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment.
https://www.science.org/doi/10.1126/sciadv.abg5686

251 EGFR activation limits the response of liver cancer to lenvatinib.
https://www.nature.com/articles/s41586-021-03741-7

250 A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
https://stm.sciencemag.org/content/13/603/eabf1383

249 Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.
https://www.nature.com/articles/s41591-020-01224-2

248 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
https://www.pnas.org/content/118/13/e2015433118

247 An ionic liquid formulation ablates tumors, uniformly distributes drugs in the ablation zone, and has synergistic effects with chemotherapy.
https://stm.sciencemag.org/content/13/580/eabe3889

246 Trastuzumab conjugated to α-amanitin kills HER2-low breast cancer cells with loss of chromosome 17p and enhances checkpoint blockade therapy.
https://stm.sciencemag.org/content/13/580/eabc6894

245 Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.
https://stm.sciencemag.org/content/12/574/eabb5647

244 The bacterial-derived metabolite inosine enhances cancer immunotherapy in mice.
https://science.sciencemag.org/content/369/6510/1481

243 Ageing in humans is associated with an increase in circulating methylmalonic acid, which induces expression of SOX4 and promotes tumour progression.
https://www.nature.com/articles/s41586-020-2630-0

242 Fasting-mimicking diet and hormone therapy induce breast cancer regression.
https://www.nature.com/articles/s41586-020-2502-7

241 Oral squamous cell carcinoma diagnosed from saliva metabolic profiling.
https://www.pnas.org/content/117/28/16167

240 A large feasibility study shows that a cancer blood test and PET-CT imaging can detect some cancers at an early stage.
https://science.sciencemag.org/content/369/6499/eabb9601

239 Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1.
https://www.pnas.org/content/117/23/13012

238 Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.
https://stm.sciencemag.org/content/12/537/eaaw0262

237 Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer.
https://stm.sciencemag.org/content/12/537/eaaz3577

236 Control of brain tumor growth by reactivating myeloid cells with niacin.
https://stm.sciencemag.org/content/12/537/eaay9924

235 Cysteine depletion induces pancreatic tumor ferroptosis in mice.
https://science.sciencemag.org/content/368/6486/85

234 Family History of Gastric Cancer and Helicobacter pylori Treatment.
https://www.nejm.org/doi/10.1056/NEJMoa1909666

233 Immunity to commensal papillomaviruses protects against skin cancer.
https://www.nature.com/articles/s41586-019-1719-9

232 Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer.
https://www.nejm.org/doi/full/10.1056/NEJMoa1903835

231 Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses.
https://stm.sciencemag.org/content/11/498/eaat8549

230 Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30723-8/fulltext

229 Ibrutinib and Venetoclax for First-Line Treatment of CLL.
https://www.nejm.org/doi/full/10.1056/NEJMoa1900574

228 Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma.
https://www.nejm.org/doi/full/10.1056/NEJMoa1817249

227 Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
https://www.pnas.org/content/116/22/10674

226 Methionine is a metabolic dependency of tumor-initiating cells.
https://www.nature.com/articles/s41591-019-0423-5

225 Preventable Cancer Burden Associated with Poor Diet in the United States.
https://academic.oup.com/jncics/advance-article/doi/10.1093/jncics/pkz034/5492023?searchresult=1

224 PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
https://www.pnas.org/content/116/20/9999

223 Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
https://www.nejm.org/doi/full/10.1056/NEJMoa1816714?query=featured_home

222 Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer.
https://www.nejm.org/doi/full/10.1056/NEJMoa1814017?query=featured_home

221 Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
https://www.pnas.org/content/116/6/2210

220 First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
https://www.nejm.org/doi/full/10.1056/NEJMoa1809064

219 Mannose impairs tumour growth and enhances chemotherapy.
https://www.nature.com/articles/s41586-018-0729-3

218 Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
http://www.pnas.org/content/115/47/E11091

217 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma.
https://www.nejm.org/doi/full/10.1056/NEJMoa1807315

216 Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.
https://www.nejm.org/doi/full/10.1056/NEJMoa1805762?query=featured_home

215 Enhanced detection of circulating tumor DNA by fragment size analysis.
http://stm.sciencemag.org/content/10/466/eaat4921

214 Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.
https://www.nejm.org/doi/full/10.1056/NEJMoa1809615

213 Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation.
https://www.nejm.org/doi/full/10.1056/NEJMoa1802905

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