Structural Biology

146 Insight into the Structure of the “Unstructured” Tau Protein.

145 Structure and mechanism of the cation–chloride cotransporter NKCC1.

144 Drugging an undruggable pocket on KRAS.

143 Proton activated channel with roles in ischemic injury is identified.

142 Structure of the IFNγ receptor complex guides design of biased agonists.

141 A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.

140 Tc toxin activation requires unfolding and refolding of a β-propeller.

139 Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution.

138 Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution.

137 Structures provide insight into how voltage-gated sodium channels function and how they can be inhibited.

136 Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1.

135 A cryo-electron microscopy structure of the insect Orco subunit, which forms ion channels with diverse olfactory receptors, reveals a tetrameric cation channel and sheds light on insect olfaction.

134 Structure of the origin recognition complex bound to DNA replication origin.

133 Structure of a human synaptic GABAA receptor.

132 Cryo-EM structure of a herpesvirus capsid at 3.1 Å.

131 The structure of huntingtin in complex with an interactor is determined to an overall resolution of 4 Å, paving the way for improved understanding of the cellular functions of this protein.

130 Structures of human PRC2 with its cofactors AEBP2 and JARID2.

129 Structure of the cold- and menthol-sensing ion channel TRPM8.

128 High-resolution D4 dopamine receptor crystal structures facilitate the discovery of new ligands.

127 The crystal structure of the bacterial potassium import complex KdpFABC shows how ATP hydrolysis is coupled to potassium transport to maintain cellular homeostasis under low potassium conditions.

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