118 Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.
http://www.sciencemag.org/content/347/6217/49.abstract
117 (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
http://www.pnas.org/content/111/50/E5455.abstract
116 In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation.
http://www.pnas.org/content/111/49/17600.abstract
115 Discovery and characterization of small molecules that target the GTPase Ral.
http://www.nature.com/nature/journal/v515/n7527/full/nature13713.html
114 A new method for linking antibodies to drugs produces conjugates with improved stability and efficacy.
http://www.nature.com/nbt/journal/v32/n10/abs/nbt.2968.html
113 Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants.
http://stm.sciencemag.org/content/6/260/260ra150
112 Sulforaphane treatment of autism spectrum disorder (ASD).
http://www.pnas.org/content/111/43/15550.abstract
111 Liposome-supported peritoneal dialysis for detoxification of drugs and endogenous metabolites.
http://stm.sciencemag.org/content/6/258/258ra141.abstract
110 Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction.
http://jop.sagepub.com/content/early/2014/09/06/0269881114548296.abstract
109 Refilling drug delivery depots through the blood.
http://www.pnas.org/content/111/35/12722.abstract
108 Inhibitor of MYC identified in a Kröhnke pyridine library.
http://www.pnas.org/content/111/34/12556.abstract
107 Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.
http://www.nature.com/nm/journal/v20/n8/abs/nm.3618.html
106 Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis.
http://www.nature.com/ncomms/2014/140722/ncomms5478/full/ncomms5478.html
105 Intravenously administered nanoparticles increase survival following blast trauma.
http://www.pnas.org/content/111/28/10293.abstract
104 Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy.
http://www.pnas.org/content/111/27/9762.abstract
103 Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring.
http://www.nature.com/nchembio/journal/v10/n7/abs/nchembio.1554.html
102 Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants.
http://www.pnas.org/content/111/26/E2711.abstract
101 Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
http://www.pnas.org/content/111/24/E2501.abstract
100 Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib.
http://www.nejm.org/doi/full/10.1056/NEJMoa1400029
99 Pasireotide for Postoperative Pancreatic Fistula.
http://www.nejm.org/doi/full/10.1056/NEJMoa1313688
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