Biotechnology

Articles:

452  Proof of concept for identifying cystic fibrosis from perspiration samples.
https://www.pnas.org/content/116/49/24408

451  A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.
https://www.cell.com/cell/fulltext/S0092-8674(19)31176-6

450  Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations.
https://www.nature.com/articles/s41563-019-0385-5

449  Search-and-replace genome editing without double-strand breaks or donor DNA.
https://www.nature.com/articles/s41586-019-1711-4

448  Engineering the stereoisomeric structure of seed oil to mimic human milk fat.
https://www.pnas.org/content/116/42/20947

447  Data storage in DNA with fewer synthesis cycles using composite DNA letters.
https://www.nature.com/articles/s41587-019-0240-x

446  Polymer nanocapsules, assembled around a ribonucleoprotein complex of Cas9 nuclease and a single-guide RNA, enable safe and efficient gene editing in vitro and in vivo.
https://www.nature.com/articles/s41565-019-0539-2

445  Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae.
https://www.pnas.org/content/116/39/19415

444  Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs.
https://www.nature.com/articles/s41587-019-0178-z

443  Engineered zinc finger nucleases achieve 98% knockout of a target gene in human T cells without detectable off-target activity.
https://www.nature.com/articles/s41587-019-0186-z

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