452  Proof of concept for identifying cystic fibrosis from perspiration samples.

451  A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

450  Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations.

449  Search-and-replace genome editing without double-strand breaks or donor DNA.

448  Engineering the stereoisomeric structure of seed oil to mimic human milk fat.

447  Data storage in DNA with fewer synthesis cycles using composite DNA letters.

446  Polymer nanocapsules, assembled around a ribonucleoprotein complex of Cas9 nuclease and a single-guide RNA, enable safe and efficient gene editing in vitro and in vivo.

445  Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae.

444  Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs.

443  Engineered zinc finger nucleases achieve 98% knockout of a target gene in human T cells without detectable off-target activity.

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