18 Fexinidazole, a drug in clinical testing for African sleeping sickness, shows potential as an oral treatment for another neglected tropical disease.
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17 Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis.
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16 Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.
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15 GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity.
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14 High-resolution dose–response screening using droplet-based microfluidics.
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13 Belimumab: A BLyS-Specific Inhibitor for the Treatment of Systemic Lupus Erythematosus.
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12 Denosumab for the Treatment of Osteoporosis and Cancer-Related Conditions.
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11 The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo.
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10 Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing.
http://www.pnas.org/content/108/52/20976.abstract
9 Imidazolopiperazine compounds inhibit liver-stage malaria parasites with one oral dose in mice.
http://www.sciencemag.org/content/334/6061/1372.abstract
8 Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase.
http://www.pnas.org/content/108/46/18849.abstract
7 Optimized mannoside compounds that block uropathogenic E. coli entry into bladder epithelium were effective in the treatment and prevention of urinary tract infections in mice.
http://stm.sciencemag.org/content/3/109/109ra115.abstract
6 A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys.
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5 Broad-Spectrum Antiviral Therapeutics.
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4 Intraductal administration of chemotherapeutic agents may reduce new breast cancer formation and offer a less toxic treatment regimen than intravenous therapy.
http://stm.sciencemag.org/content/3/106/106ra108.abstract
3 Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins.
http://www.sciencemag.org/content/334/6055/498.abstract
2 Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. Zasloff M. et al. (2011). PNAS 108: 15978-15983.
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1 The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys. Webster SJ et al. (2011). BJP
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