38 A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine.
http://www.sciencemag.org/content/336/6089/1704.abstract
37 Large-scale prediction and testing of drug activity on side-effect targets.
http://www.nature.com/nature/journal/v486/n7403/full/nature11159.html
36 Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
http://www.pnas.org/content/109/24/9629.abstract
35 Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.
http://www.pnas.org/content/109/24/9623.abstract
34 Amorfrutins are potent antidiabetic dietary natural products.
http://www.pnas.org/content/109/19/7257
33 Resolvins and protectins are anti-inflammatory and pro-resolving lipid mediators that are shown to resolve infections, and their administration lowers required doses of antibiotics and shortens infections.
http://www.nature.com/nature/journal/v484/n7395/full/nature11042.html
32 1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation: Identification of Activity, Formulation, and Randomised, Controlled Trials.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0035419
31 Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity.
http://www.nature.com/nchem/journal/v4/n1/abs/nchem.1206.html
30 Quantifying the chemical beauty of drugs.
http://www.nature.com/nchem/journal/v4/n2/abs/nchem.1243.html
29 High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
http://www.pnas.org/content/109/14/5423.abstract
28 Bexarotene counters the effects of neurodegenerative disease in mice.
http://www.sciencemag.org/content/335/6075/1503.abstract
27 A new drug blocks platelet aggregation by interacting with the integrin receptor differently from current drugs that cause adverse side effects.
http://stm.sciencemag.org/content/4/125/125ra32.abstract
26 Lithium enhances remyelination of peripheral nerves.
http://www.pnas.org/content/109/10/3973.abstract
25 Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
http://www.pnas.org/content/109/9/3510
24 Implanted in humans, a wirelessly controlled, microchip-based drug delivery device demonstrates pharmacokinetic profiles of an anti-osteoporosis drug that are similar to subcutaneous injections.
http://stm.sciencemag.org/content/4/122/122ra21.abstract
23 Azithromycin distinctively modulates classical activation of human monocytes in vitro.
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01576.x/abstract
22 Amphotericin primarily kills yeast by simply binding ergosterol.
http://www.pnas.org/content/109/7/2234.abstract
21 esveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases.
http://www.cell.com/abstract/S0092-8674(12)00030-X
20 Primary amines protect against retinal degeneration in mouse models of retinopathies.
http://www.nature.com/nchembio/journal/v8/n2/abs/nchembio.759.html
19 Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
http://www.nature.com/nchembio/journal/v8/n2/abs/nchembio.761.html
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