98 Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection.
http://www.nejm.org/doi/full/10.1056/NEJMoa1402454
97 Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs.
http://stm.sciencemag.org/content/6/240/240ra73
96 Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis.
http://stm.sciencemag.org/content/6/240/240ra76
95 Letermovir for Cytomegalovirus Prophylaxis in Hematopoietic-Cell Transplantation.
http://www.nejm.org/doi/full/10.1056/NEJMoa1309533
94 Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action.
http://www.nature.com/ncomms/2014/140604/ncomms5029/full/ncomms5029.html
93 In vivo imaging of specific drug–target binding at subcellular resolution.
http://www.nature.com/ncomms/2014/140528/ncomms4946/full/ncomms4946.html
92 The small molecule Remodelin can correct nuclear architecture defects and improve cellular fitness of progeric human cells.
http://www.sciencemag.org/content/344/6183/527.abstract
91 The delivery of therapeutics using an external trigger is an attractive route for the improvement of targeted disease treatment. Here, the authors have discovered a porphyrin–phospholipid liposome for light-controlled membrane permeabilization and use the system to deliver an anticancer drug in vivo.
http://www.nature.com/ncomms/2014/140403/ncomms4546/full/ncomms4546.html
90 Therapeutic vaccine against DPP4 improves glucose metabolism in mice.
http://www.pnas.org/content/111/13/E1256.abstract
89 A highly efficient cocaine-detoxifying enzyme obtained by computational design.
http://www.nature.com/ncomms/2014/140318/ncomms4457/full/ncomms4457.html
88 Comparison of Pregabalin with Pramipexole for Restless Legs Syndrome.
http://www.nejm.org/doi/full/10.1056/NEJMoa1303646
87 Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics.
http://www.sciencemag.org/content/343/6175/1140.abstract
86 Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
http://www.nature.com/nm/journal/v20/n2/abs/nm.3458.html
85 Controlled release of an anti-cancer drug from DNA structured nano-films.
http://www.nature.com/srep/2014/140212/srep04078/full/srep04078.html
84 Sloth Hair as a Novel Source of Fungi with Potent Anti-Parasitic, Anti-Cancer and Anti-Bacterial Bioactivity.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084549
83 Near-infrared–actuated devices for remotely controlled drug delivery.
http://www.pnas.org/content/111/4/1349.abstract
82 Neonatal Estradiol Stimulation Prevents Epilepsy in Arx Model of X-Linked Infantile Spasms Syndrome.
http://stm.sciencemag.org/content/6/220/220ra12
81 Erythropoietin Derived by Chemical Synthesis.
http://www.sciencemag.org/content/342/6164/1357.abstract
80 Development of small-molecule inhibitors targeting adipose triglyceride lipase.
http://www.nature.com/nchembio/journal/v9/n12/abs/nchembio.1359.html
79 The small-molecule indolcarboxamide is a potential drug candidate for treating multidrug-resistant tuberculosis.
http://stm.sciencemag.org/content/5/214/214ra168.abstract
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