78 A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
http://www.nature.com/nature/journal/v503/n7477/full/nature12656.html
77 Combining two strategies to improve perfusion and drug delivery in solid tumors.
http://www.pnas.org/content/110/46/18632.abstract
76 Human genome–guided identification of memory-modulating drugs.
http://www.pnas.org/content/110/46/E4369.abstract
75 Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De Koninck and his colleagues report that they have developed a novel small-molecule compound that is orally bioavailable and can activate KCC2 and reduce chronic pain in rats.
http://www.nature.com/nm/journal/v19/n11/abs/nm.3356.html
74 Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin.
http://www.nature.com/ncomms/2013/131016/ncomms3603/full/ncomms3603.html
73 Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/297/ra90
72 Bio-inspired voltage-dependent calcium channel blockers.
http://www.nature.com/ncomms/2013/131007/ncomms3540/full/ncomms3540.html
71 Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules.
http://www.pnas.org/content/110/40/16169.abstract
70 Development of a histone deacetylase 6 inhibitor and its biological effects.
http://www.pnas.org/content/110/39/15704.abstract
69 Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
http://www.pnas.org/content/110/36/E3445.abstract
68 The first total synthesis of the cyclodepsipeptide pipecolidepsin A.
http://www.nature.com/ncomms/2013/130830/ncomms3352/full/ncomms3352.html
67 A chemical route to a diterpenoid could enhance production efficiency of a drug that treats a precancerous skin condition.
http://www.sciencemag.org/content/341/6148/878.abstract
66 Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis.
http://www.pnas.org/content/110/33/13594.abstract
65 Metformin improves healthspan and lifespan in mice.
http://www.nature.com/ncomms/2013/130730/ncomms3192/full/ncomms3192.html
64 Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma.
http://www.pnas.org/content/110/29/11751.abstract
63 Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.
http://www.pnas.org/content/110/29/11797.abstract
62 A method to monitor drug binding to proteins in cells may help in target validation and drug optimization.
http://www.sciencemag.org/content/341/6141/84.abstract
61 Chemical and genetic validation of thiamine utilization as an antimalarial drug target.
http://www.nature.com/ncomms/2013/130627/ncomms3060/full/ncomms3060.html
60 Silver enhances the activity of a wide range of antibiotics and broadens the spectrum of vancomycin, rendering it effective against Gram-negative bacteria.
http://stm.sciencemag.org/content/5/190/190ra81.abstract
59 Clomiphene and toremifene inhibit Ebola virus infection.
http://stm.sciencemag.org/content/5/190/190ra79.abstract
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