54 High-grade serous ovarian cancer arises from fallopian tube in a mouse model.
http://www.pnas.org/content/109/10/3921
53 Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.
http://www.nature.com/nm/journal/v18/n2/abs/nm.2608.html
52 Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal growth factor receptor (EGFR) in response to BRAF inhibition.
http://www.nature.com/nature/journal/v483/n7387/full/nature10868.html
51 Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032521
50 TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types.
http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00037-2
49 A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma.
http://www.cell.com/cancer-cell/fulltext/S1535-6108(12)00002-5
48 Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer.
http://www.cell.com/abstract/S0092-8674(12)00081-5
47 TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers.
http://www.cell.com/abstract/S0092-8674(12)00102-X
46 A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals.
http://www.nature.com/srep/2012/120221/srep00280/full/srep00280.html
45 Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.
http://www.jci.org/articles/view/59227
44 CBX7 is a tumor suppressor in mice and humans.
http://www.jci.org/articles/view/58620
43 An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
http://www.jci.org/articles/view/59309
42 Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
http://jem.rupress.org/content/209/2/275.abstract
41 Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA.
http://www.pnas.org/content/109/8/3024.abstract
40 Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
http://www.pnas.org/content/109/8/2784.abstract
39 Defining the cellular precursors to human breast cancer.
http://www.pnas.org/content/109/8/2772.abstract
38 Leukocyte composition of human breast cancer.
http://www.pnas.org/content/109/8/2796.abstract
37 Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells.
http://www.pnas.org/content/109/8/2778.abstract
36 Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses.
http://stm.sciencemag.org/content/4/120/120ra16.abstract
35 Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.
http://www.pnas.org/content/109/6/2066.abstract
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