34 Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.
http://www.pnas.org/content/109/6/E353.abstract
33 Recurrent histone mutations are linked to paediatric glioblastoma multiforme, an aggressive type of brain tumour.
http://www.nature.com/nature/journal/v482/n7384/full/nature10833.html
32 A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer.
http://www.cell.com/cell-stem-cell/abstract/S1934-5909(12)00002-1
31 Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas.
http://www.nature.com/neuro/journal/v15/n2/abs/nn.3019.html
30 Key contribution of CPEB4-mediated translational control to cancer progression.
http://www.nature.com/nm/journal/v18/n1/abs/nm.2540.html
29 The structures of CYP17A1 with steroid inhibitors abiraterone or TOK-001 provide a better understanding of the enzyme’s catalytic capabilities and inhibition, and hence assist in understanding steroidogenic diseases and designing drugs to improve the treatment of prostate and other steroid-responsive cancers.
http://www.nature.com/nature/journal/v482/n7383/full/nature10743.html
28 Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.
http://www.pnas.org/content/109/5/1643.abstract
27 Brush border Myosin Ia has tumor suppressor activity in the intestine.
http://www.pnas.org/content/109/5/1530.abstract
26 Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029534
25 High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030940
24 The sequencing of AML genomes of eight patients before and after relapse reveals two major patterns of clonal evolution, with chemotherapy appearing to have a role in both patterns.
http://www.nature.com/nature/journal/v481/n7382/full/nature10738.html
23 EMT and Dissemination Precede Pancreatic Tumor Formation.
http://www.cell.com/abstract/S0092-8674(11)01369-9
22 An RNA interference screen identifies a “druggable” enzyme whose inhibition halts tumor cell growth.
http://www.sciencemag.org/content/335/6066/348.abstract
21 Reductive carboxylation supports growth in tumour cells with defective mitochondria.
http://www.nature.com/nature/journal/v481/n7381/full/nature10642.html
20 The retinoblastoma genome is shown to be stable, but multiple cancer pathways are identified that are epigenetically deregulated, providing potential new therapeutic targets.
http://www.nature.com/nature/journal/v481/n7381/full/nature10733.html
19 The microRNA miR-126 suppresses the formation of breast cancer metastases via the suppression of several novel pro-angiogenic genes that cooperate in the recruitment of endothelial cells, leading to the formation of metastatic colonies.
http://www.nature.com/nature/journal/v481/n7380/full/nature10661.html
18 Epigenetic Changes of CXCR4 and Its Ligand CXCL12 as Prognostic Factors for Sporadic Breast Cancer.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029461
17 The functional crosstalk between Wnt/β-catenin and BRAF signaling may yield more effective therapies for treating melanoma.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/206/ra3
16 2-Hydroxyglutarate, a metabolite overproduced in IDH-mutated gliomas, can be detected noninvasively in patients with brain tumors by optimized magnetic resonance spectroscopy.
http://stm.sciencemag.org/content/4/116/116ra4.abstract
15 Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer.
http://www.nejm.org/doi/full/10.1056/NEJMoa1113216
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