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259 Statins enhance the efficacy of HER2-targeting radioligand therapy in drug-resistant gastric cancers.

258 Brown-fat-mediated tumour suppression by cold-altered global metabolism.

257 Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation.

256 Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer.

255 PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer.

254 Trastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer.

253 Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors.

252 Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment.

251 EGFR activation limits the response of liver cancer to lenvatinib.

250 A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.

249 Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.

248 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.

247 An ionic liquid formulation ablates tumors, uniformly distributes drugs in the ablation zone, and has synergistic effects with chemotherapy.

246 Trastuzumab conjugated to α-amanitin kills HER2-low breast cancer cells with loss of chromosome 17p and enhances checkpoint blockade therapy.

245 Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.

244 The bacterial-derived metabolite inosine enhances cancer immunotherapy in mice.

243 Ageing in humans is associated with an increase in circulating methylmalonic acid, which induces expression of SOX4 and promotes tumour progression.

242 Fasting-mimicking diet and hormone therapy induce breast cancer regression.

241 Oral squamous cell carcinoma diagnosed from saliva metabolic profiling.

240 A large feasibility study shows that a cancer blood test and PET-CT imaging can detect some cancers at an early stage.

239 Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1.

238 Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.

237 Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer.

236 Control of brain tumor growth by reactivating myeloid cells with niacin.

235 Cysteine depletion induces pancreatic tumor ferroptosis in mice.

234 Family History of Gastric Cancer and Helicobacter pylori Treatment.

233 Immunity to commensal papillomaviruses protects against skin cancer.

232 Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer.

231 Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses.

230 Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial.

229 Ibrutinib and Venetoclax for First-Line Treatment of CLL.

228 Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma.

227 Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.

226 Methionine is a metabolic dependency of tumor-initiating cells.

225 Preventable Cancer Burden Associated with Poor Diet in the United States.

224 PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.

223 Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

222 Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer.

221 Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.

220 First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.

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