113 The economic burden of physical inactivity.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30383-X/fulltext
112 Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality?
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30370-1/fulltext
111 Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30175-1/fulltext
110 Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1512711
109 Indacaterol–Glycopyrronium versus Salmeterol–Fluticasone for COPD.
http://www.nejm.org/doi/full/10.1056/NEJMoa1516385
108 Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30363-4/abstract
107 Blue light reduces organ injury from ischemia and reperfusion.
http://www.pnas.org/content/113/19/5239.abstract
106 Tocilizumab for induction and maintenance of remission in giant cell arteritis.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00560-2/abstract
105 Sustained-release dexamfetamine in the treatment of chronic cocaine-dependent patients on heroin-assisted treatment.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00205-1/abstract
104 In-vivo oesophageal regeneration in a human being by use of a non-biological scaffold and extracellular matrix.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)01036-3/abstract
103 Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30310-5/abstract
102 A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery.
http://www.nejm.org/doi/full/10.1056/NEJMoa1511048
101 Effects of Testosterone Treatment in Older Men.
http://www.nejm.org/doi/full/10.1056/NEJMoa1506119
100 NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction.
http://www.nature.com/ncomms/2016/160419/ncomms11361/full/ncomms11361.html
99 Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform.
http://stm.sciencemag.org/content/8/333/333ra49
98 Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice.
http://www.nature.com/nm/journal/v22/n2/full/nm.4021.html
97 Induction of labour at term with oral misoprostol versus a Foley catheter.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00084-2/abstract
96 A Randomized Trial of Low-Cost Mesh in Groin Hernia Repair.
http://www.nejm.org/doi/full/10.1056/NEJMoa1505126
95 Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus.
http://www.nejm.org/doi/full/10.1056/NEJMoa1509819
94 Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity.
http://www.nejm.org/doi/full/10.1056/NEJMoa1510991
93 Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1505066
92 A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds.
http://www.nejm.org/doi/full/10.1056/NEJMoa1508502
91 Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00803-X/abstract
90 A new deep proteomic analysis method is used to identify proteins that interact with wild-type cystic fibrosis transmembrane conductance regulator (CFTR) and its mutant version that is the major cause of cystic fibrosis.
http://www.nature.com/nature/journal/v528/n7583/full/nature15729.html
89 Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker.
http://stm.sciencemag.org/content/7/316/316ra193
88 Fourteen babies born after round spermatid injection into human oocytes.
http://www.pnas.org/content/112/47/14629.abstract
87 Roundworm and hookworm infections are associated with contrasting effects on human reproduction.
http://www.sciencemag.org/content/350/6263/970.abstract
86 Early Inhaled Budesonide for the Prevention of Bronchopulmonary Dysplasia.
http://www.nejm.org/doi/full/10.1056/NEJMoa1501917
85 Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
http://www.nejm.org/doi/full/10.1056/NEJMoa1504942
84 Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility.
http://www.nejm.org/doi/full/10.1056/NEJMoa1414827
83 Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1503824
82 Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1412679
81 Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1501481
80 A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy.
http://www.pnas.org/content/112/41/12864.abstract
79 Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy.
http://www.nature.com/ncomms/2015/151013/ncomms9506/full/ncomms9506.html
78 Small bites versus large bites for closure of abdominal midline incisions (STITCH): a double-blind, multicentre, randomised controlled trial.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60459-7/abstract
77 Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria.
http://www.nejm.org/doi/full/10.1056/NEJMoa1502950
76 A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency.
http://www.nejm.org/doi/full/10.1056/NEJMoa1501365
75 Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.
http://www.nejm.org/doi/full/10.1056/NEJMoa1413687
74 Association of Electronic Cigarette Use With Initiation of Combustible Tobacco Product Smoking in Early Adolescence.
http://jama.jamanetwork.com/article.aspx?articleid=2428954
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