Organic Chemistry

102 Direct coupling of aliphatic C–H nucleophiles to aryl electrophiles is described, through the combination of light-driven polyoxometalate hydrogen atom transfer and nickel catalysis.

101 A vitamin-inspired organic catalyst brings together an amine and an imine to yield α,β-diamino acid esters.

100 Synthesis of partially and fully fused polyaromatics by annulative chlorophenylene dimerization.

99 Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.

98 Mild oxidation of methane to methanol or acetic acid on supported isolated rhodium catalysts.

97 Cobalt nanoparticles prepared from a metal-organic framework precursor catalyze a very broad range of reductive aminations.

96 Methyl radicals generated catalytically from methane with aqueous hydrogen peroxide are converted to methanol with oxygen.

95 When immiscible becomes miscible—Methane in water at high pressures.

94 Remote carboxylation of halogenated aliphatic hydrocarbons with carbon dioxide.

93 Active sites for CO2 hydrogenation to methanol on Cu/ZnO catalysts.

92 One-pot synthesis of amino acid precursors with insoluble organic matter in planetesimals with aqueous activity.

91 Synthesis of ketones from biomass-derived feedstock.

90 Macrocyclic bis-thioureas catalyze stereospecific glycosylation reactions.

89 Molecular ligand modulation of palladium nanocatalysts for highly efficient and robust heterogeneous oxidation of cyclohexenone to phenol.

88 Boron nitride, often considered unreactive, can be a highly active and selective catalyst for propane oxidation to propene.

87 Synthesis of resveratrol tetramers via a stereoconvergent radical equilibrium.

86 The flavouring, perfume and pharmaceutical industries rely on the selective hydrogenation of α,β-unsaturated aldehydes to generate unsaturated alcohols; here, a new type of highly selective catalyst is described in which platinum nanoparticles are sandwiched between a core and a shell of a metal−organic framework.

85 Rational Molecular Design for Achieving Persistent and Efficient Pure Organic Room-Temperature Phosphorescence.

84 Catalytic enantioselective 1,6-conjugate additions of propargyl and allyl groups.

83 The long-sought direct formation of a bond between two sp3-hybridized carbon atoms is achieved by the merger of photoredox and nickel catalysis using only simple carboxylic acids and alkyl halides as starting materials.

82 Cyclic polymers from alkynes.

81 Direct conversion of methane to aromatics in a catalytic co-ionic membrane reactor.

80 Computational and experimental investigations of one-step conversion of poly(carbonate)s into value-added poly(aryl ether sulfone)s.

79 Sugar Synthesis from CO2 in Escherichia coli.

78 Selective catalytic two-step process for ethylene glycol from carbon monoxide.

77 Quantifying the promotion of Cu catalysts by ZnO for methanol synthesis.

76 Photochemical route for synthesizing atomically dispersed palladium catalysts.

75 The idea of carbon–hydrogen functionalization, in which C–H bonds are modified at will, represents a paradigm shift in the standard logic of organic synthesis; here, dirhodium catalysts are used to achieve highly site-selective, diastereoselective and enantioselective C–H functionalization of n-alkanes and terminally substituted n-alkyl compounds.

74 Here, a method is described by which to generate all possible stereoisomers of certain amino alcohols—a protocol that should see use in drug discovery and development, where it is important to determine the differing effects of stereoisomeric drug candidates.

73 Nineteen-step total synthesis of (+)-phorbol.

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