Organic Chemistry

124 A methylphenanthroline iridium catalyst rapidly adds boron to primary C–H bonds and beta C–H bonds in saturated heterocycles.

123 A one-step, three-component radical coupling of [1.1.1]propellane by a photoredox reaction mediated by a copper catalyst produces drug-like bicyclopentanes.

122 Various rare sugars that cannot be isolated from natural sources are synthesized using light-driven epimerization, a process which may find application in other synthetic scenarios.

121 Molecular tuning of CO2-to-ethylene conversion.

120 Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles.

119 A catalyst system concentrates hydrogen peroxide and methane in close proximity for efficient methanol synthesis.

118 Individual cobalt phthalocyanine derivative molecules immobilized on carbon nanotubes effectively catalyse the electroreduction of CO2 to methanol via a domino process with high activity and selectivity and stable performance.

117 Highly enantioselective carbene insertion into N–H bonds of aliphatic amines.

116 A broadly applicable cross-linker for aliphatic polymers containing C–H bonds.

115 The chemical synthesis of (+)-perseanol, a diterpene with potent insecticidal properties, is reported.

114 An sp-hybridized molecular carbon allotrope, cyclo[18]carbon.

113 A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements.

112 Quaternary-centre-guided synthesis of complex polycyclic terpenes.

111 Catalysis by chromium and titanium complexes forms alcohols by adding hydrogen to the more-substituted carbon of epoxides.

110 Cleavage of the bond between saturated and double-bonded carbons by ozone and iron can diversify abundant natural products.

109 Molybdenum-catalysed ammonia production with samarium diiodide and alcohols or water.

108 Electrochemical conversion of methane to ethylene in a solid oxide electrolyzer.

107 Aromatization-driven C–C bond activation through iridium/phosphine catalysis enables deacylative transformations in various ketone substrates.

106 Catalyst-free, highly selective synthesis of ammonia from nitrogen and water by a plasma electrolytic system.

105 A nickel catalyst selectively converts terminal olefins into internal olefins with trans geometry via a radical mechanism.

104 A metal-binding peptide becomes a potent catalyst for ester hydrolysis.

103 Photochemical deracemization through irradiation with visible light in the presence of a chiral sensitizer enables the direct formation of single enantiomers from a racemic mixture of the same compound.

102 Direct coupling of aliphatic C–H nucleophiles to aryl electrophiles is described, through the combination of light-driven polyoxometalate hydrogen atom transfer and nickel catalysis.

101 A vitamin-inspired organic catalyst brings together an amine and an imine to yield α,β-diamino acid esters.

100 Synthesis of partially and fully fused polyaromatics by annulative chlorophenylene dimerization.

99 Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.

98 Mild oxidation of methane to methanol or acetic acid on supported isolated rhodium catalysts.

97 Cobalt nanoparticles prepared from a metal-organic framework precursor catalyze a very broad range of reductive aminations.

96 Methyl radicals generated catalytically from methane with aqueous hydrogen peroxide are converted to methanol with oxygen.

95 When immiscible becomes miscible—Methane in water at high pressures.

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