Organic Chemistry

Articles:
141 Preparation of methanediamine (CH2(NH2)2)—A precursor to nucleobases in the interstellar medium.
https://www.pnas.org/doi/10.1073/pnas.2217329119

140 Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis.
https://www.science.org/doi/10.1126/science.abn7565

139 Making hydrogen peroxide in situ could improve overall process efficiency for production of a key nylon precursor.
https://www.science.org/doi/10.1126/science.abl4822

138 The state of zinc in methanol synthesis over a Zn/ZnO/Cu(211) model catalyst.
https://www.science.org/doi/10.1126/science.abj7747

137 Catalytic synthesis of phenols with nitrous oxide.
https://www.nature.com/articles/s41586-022-04516-4

136 Synthesis of a natural product and derivatives by a late-stage oxidative dimerization sheds light on its antibiotic activity.
https://www.science.org/doi/10.1126/science.abm6509

135 Modular terpene synthesis enabled by mild electrochemical couplings.
https://www.science.org/doi/10.1126/science.abn1395

134 Carbon nanotube supported oriented metal organic framework membrane for effective ethylene/ethane separation.
https://www.science.org/doi/10.1126/sciadv.abm6741

133 Synthesis of methanediol [CH2(OH)2]: The simplest geminal diol.
https://www.pnas.org/content/119/1/e2111938119

132 A solution of ethylene diamine and lithium in tetrahydrofuran rapidly and selectively reduces aromatics.
https://www.science.org/doi/10.1126/science.abk3099

131 Cleaving arene rings for acyclic alkenylnitrile synthesis.
https://www.nature.com/articles/s41586-021-03801-y

130 Diamines are formed at benzylic and adjacent alkyl carbons using acetonitrile as the nitrogen source.
https://science.sciencemag.org/content/371/6529/620

129 A software platform translates the organic chemistry literature into a format executable by automated laboratory apparatus.
https://science.sciencemag.org/content/370/6512/101

128 A photochemical dehydrogenative strategy for aniline synthesis.
https://www.nature.com/articles/s41586-020-2539-7

127 Common organic reactions mechanically perturb solvents and increase molecular mobility beyond simple Brownian diffusion.
https://science.sciencemag.org/content/369/6503/537

126 Ammonia is synthesized using a dual-site approach, whereby nitrogen vacancies on LaN activate N2, which then reacts with hydrogen atoms produced over the Ni metal to give ammonia.
https://www.nature.com/articles/s41586-020-2464-9

125 Rationally designed indium oxide catalysts for CO2 hydrogenation to methanol with high activity and selectivity.
https://advances.sciencemag.org/content/6/25/eaaz2060

124 A methylphenanthroline iridium catalyst rapidly adds boron to primary C–H bonds and beta C–H bonds in saturated heterocycles.
https://science.sciencemag.org/content/368/6492/736

123 A one-step, three-component radical coupling of [1.1.1]propellane by a photoredox reaction mediated by a copper catalyst produces drug-like bicyclopentanes.
https://www.nature.com/articles/s41586-020-2060-z

122 Various rare sugars that cannot be isolated from natural sources are synthesized using light-driven epimerization, a process which may find application in other synthetic scenarios.
https://www.nature.com/articles/s41586-020-1937-1

121 Molecular tuning of CO2-to-ethylene conversion.
https://www.nature.com/articles/s41586-019-1782-2

120 Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles.
https://science.sciencemag.org/content/367/6475/281

119 A catalyst system concentrates hydrogen peroxide and methane in close proximity for efficient methanol synthesis.
https://science.sciencemag.org/content/367/6474/193

118 Individual cobalt phthalocyanine derivative molecules immobilized on carbon nanotubes effectively catalyse the electroreduction of CO2 to methanol via a domino process with high activity and selectivity and stable performance.
https://www.nature.com/articles/s41586-019-1760-8

117 Highly enantioselective carbene insertion into N–H bonds of aliphatic amines.
https://science.sciencemag.org/content/366/6468/990

116 A broadly applicable cross-linker for aliphatic polymers containing C–H bonds.
https://science.sciencemag.org/content/366/6467/875

115 The chemical synthesis of (+)-perseanol, a diterpene with potent insecticidal properties, is reported.
https://www.nature.com/articles/s41586-019-1580-x

114 An sp-hybridized molecular carbon allotrope, cyclo[18]carbon.
https://science.sciencemag.org/content/early/2019/08/14/science.aay1914

113 A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements.
https://www.nature.com/articles/s41586-019-1260-x

112 Quaternary-centre-guided synthesis of complex polycyclic terpenes.
https://www.nature.com/articles/s41586-019-1179-2

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