21 miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. Kuhn S, et al. (2011). PNAS 108: 2355-2360.
http://www.pnas.org/content/108/6/2355.abstract
20 Transgenic birds expressing a short hairpin RNA that blocks viral polymerase hinder influenza transmission.
http://www.sciencemag.org/content/331/6014/223.abstract
19 The transition from androgen-dependent to castration-resistant prostate cancer is a lethal event. N-cadherin seems to be a major cause underlying this transition, and targeting this adhesion molecule may have positive clinical benefit.
Tanaka H, et al. (2010). Nature Medicine 16:1414–1420.
http://www.nature.com/nm/journal/v16/n12/abs/nm.2236.html
18 Chemical synthesis of the mouse mitochondrial genome.
Gibson DG et al. (2010). Nature Methods 7: 901-903.
http://www.nature.com/nmeth/journal/v7/n11/abs/nmeth.1515.html
17 A eukaryotic protein complex helps detect and destroy "aberrant" messenger RNAs stalled on ribosomes.
Shoemaker CJ, et al. (2010) Science 330: 369-372.
http://www.sciencemag.org/cgi/content/abstract/330/6002/369
16 Structural mimics for L-cystine may provide drug treatments for certain types of kidney stones.
Rimer JD, et al. (2010) Science 330: 337-341.
http://www.sciencemag.org/cgi/content/abstract/330/6002/337
15 Selective cell death mediated by small conditional RNAs. The authors describe small conditional RNAs that undergo hybridization chain reactions (HCR) to induce cell death via an innate immune response if and only if a cognate mRNA cancer marker is detected within a cell.
Venkataraman S. et al. (2010). PNAS 107: 16777-16782.
http://www.pnas.org/content/107/39/16777.abstract
14 Membrane remodeling induced by the dynamin-related protein drp1 stimulates bax oligomerization.
Montessuit S, Somasekharan SP et al. (2010) Cell 142: 889-901.
http://www.cell.com/abstract/S0092-8674(10)00948-7
13 Cell death by apoptosis is crucial for tissue development and function, and occurs throughout life. Apoptotic cells must be cleared by phagocytic cells, but the mechanisms that regulate cell clearance in vivo remain unclear. A conserved engulfment protein, ELMO1, is shown to be required for the phagocytic clearance of apoptotic germ cells.
Elliott MR. et al. (2010). Nature 467: 333-337.
http://www.nature.com/nature/journal/v467/n7313/abs/nature09356.html
12 Disorders caused by abnormal β-globin, such as β-thalassaemia, are the most prevalent inherited disorders worldwide. For treatment, many patients are dependent on blood transfusions; thus far the only cure has involved matched transplantation of haematopoietic stem cells. Here it is shown that lentiviral β-globin gene transfer can be an effective substitute for regular transfusions in a patient with severe β-thalassaemia.
Cavazzana-Calvo M et al. (2010). Nature 467: 318-322.
http://www.nature.com/nature/journal/v467/n7313/abs/nature09328.html
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