281 The kinase Mst1, which acts in the Hippo pathway, controls cell proliferation, differentiation and apoptosis. Junichi Sadoshima and his colleagues show that Mst1 in cardiomyocytes phosphorylates the protein Beclin1 to coordinately suppress autophagy and promote apoptosis, thereby having deleterious effects on the heart.
http://www.nature.com/nm/journal/v19/n11/abs/nm.3322.html
280 Interrupting mitochondrial fusion inhibits cardiac differentiation by dysregulating a specific cell signaling pathway.
http://www.sciencemag.org/content/342/6159/734.abstract
279 Visualization and targeted disruption of protein interactions in living cells.
http://www.nature.com/ncomms/2013/131024/ncomms3660/full/ncomms3660.html
278 ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair.
http://www.pnas.org/content/110/44/17927.abstract
277 Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.
http://www.nature.com/nature/journal/v502/n7471/full/nature12537.html
276 Migrating bubble during break-induced replication drives conservative DNA synthesis.
http://www.nature.com/nature/journal/v502/n7471/full/nature12584.html
275 SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing.
http://www.cell.com/developmental-cell/abstract/S1534-5807(13)00503-0
274 The Bacterial Effector VopL Organizes Actin into Filament-like Structures.
http://www.cell.com/abstract/S0092-8674(13)01156-2
273 Functional interaction between autophagy and ciliogenesis.
http://www.nature.com/nature/journal/v502/n7470/full/nature12639.html
272 HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis.
http://www.pnas.org/content/110/41/16568.abstract
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