Molecular Biology


476  RNA m6A methylation regulates the ultraviolet-induced DNA damage response.

475  A technique called genome architecture mapping (GAM) involves sequencing DNA from a large number of thin nuclear cryosections to develop a map of genome organization without the limitations of existing 3C-based methods.

474  Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers.

473  Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor.

472  An atlas of human long non-coding RNAs with accurate 5′ ends.

471  Adipose-derived circulating miRNAs regulate gene expression in other tissues.

470  Genome-wide mapping of autonomous promoter activity in human cells.

469  Imaging proteins at the single-molecule level.

468  New CRISPR–Cas systems from uncultivated microbes.

467  The application of genome-wide CRISPR–Cas9 screening coupled with a fluorescent reporter to interrogate the microRNA pathway reveals that continual transient phosphorylation of Argonaute 2 is required to maintain the global efficiency of microRNA-mediated repression.

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