434 Comprehensive molecular profiling of lung adenocarcinoma.
http://www.nature.com/nature/journal/v511/n7511/full/nature13385.html
433 Inducing changes in the levels of the MYC oncoprotein is shown to activate and repress specific sets of target genes that are characteristic of tumour cells, providing an insight into the mechanism by which MYC can stimulate tumorigenesis in contrast to its physiological role.
http://www.nature.com/nature/journal/v511/n7510/full/nature13473.html
432 Pulsed, ultrahigh dose-rate irradiation is safer than standard radiotherapy for the treatment of lung cancer and selectively spares normal tissue.
http://stm.sciencemag.org/content/6/245/245ra93.abstract
431 Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
http://www.pnas.org/content/111/28/10299.abstract
430 Engineered nanomedicine for myeloma and bone microenvironment targeting.
http://www.pnas.org/content/111/28/10287.abstract
429 Macroscopic Stiffness of Breast Tumors Predicts Metastasis.
http://www.nature.com/srep/2014/140701/srep05512/full/srep05512.html
428 Association of fruit and vegetables with the risk of nasopharyngeal cancer: Evidence from a meta-analysis.
http://www.nature.com/srep/2014/140610/srep05229/full/srep05229.html
427 SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.
http://www.nature.com/nature/journal/v511/n7508/full/nature13305.html
426 Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.
http://stke.sciencemag.org/cgi/content/abstract/7/332/ra63
425 A new mechanism by which acute myeloid leukaemia patients become resistant to Ara-C and a newer treatment, ribavirin, is uncovered; these drugs can be glucuronidated and thereby inactivated by members of the UDP glucuronosyltransferase family of enzymes activated through GLI1 signalling.
http://www.nature.com/nature/journal/v511/n7507/full/nature13283.html
424 COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models.
http://stm.sciencemag.org/content/6/242/242ra84.abstract
423 Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
http://www.nature.com/nature/journal/v510/n7505/full/nature13444.html
422 Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
http://www.nature.com/ncomms/2014/140625/ncomms5255/full/ncomms5255.html
421 Screening individual cancer cells within a brain tumor may help to guide treatment and predict prognosis.
http://www.sciencemag.org/content/344/6190/1396.abstract
420 Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
http://www.nature.com/nature/journal/v510/n7504/full/nature13229.html
419 Copper chelators could help to reduce metastasis from breast tumors.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/329/ra56
418 PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors.
http://www.pnas.org/content/111/23/E2404.abstract
417 Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach.
http://www.nature.com/ncomms/2014/140603/ncomms5006/full/ncomms5006.html
416 Improved Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients.
http://stm.sciencemag.org/content/6/238/238ra70
415 Targeting Poly(ADP-Ribose) Polymerase and the c-Myb–Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer.
http://stke.sciencemag.org/cgi/content/abstract/7/326/ra47
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