950 Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.
http://science.sciencemag.org/content/362/6418/1055
949 Single-cell multiomics sequencing and analyses of human colorectal cancer.
http://science.sciencemag.org/content/362/6418/1060
948 Mannose impairs tumour growth and enhances chemotherapy.
https://www.nature.com/articles/s41586-018-0729-3
947 Cancer-associated mutations are surprisingly common in normal esophageal epithelium from human donors.
http://science.sciencemag.org/content/362/6417/911
946 Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
http://www.pnas.org/content/115/47/E11091
945 The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
https://www.nature.com/articles/s41586-018-0701-2
944 An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.
https://www.nature.com/articles/s41586-018-0703-0
943 Autophagy maintains tumour growth through circulating arginine.
https://www.nature.com/articles/s41586-018-0697-7
942 Enhanced detection of circulating tumor DNA by fragment size analysis.
http://stm.sciencemag.org/content/10/466/eaat4921
941 Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
https://www.nature.com/articles/s41586-018-0629-6
940 Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer.
https://pubs.acs.org/doi/10.1021/acsnano.8b02481
939 Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers.
https://pubs.acs.org/doi/10.1021/acsnano.8b00967
938 Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.
https://pubs.acs.org/doi/10.1021/acsnano.8b04146
937 Enhanced Transdermal Drug Delivery by Transfersome-Embedded Oligopeptide Hydrogel for Topical Chemotherapy of Melanoma.
https://pubs.acs.org/doi/10.1021/acsnano.8b03800
936 Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma.
http://stm.sciencemag.org/content/10/464/eaat3487
935 Chromatin accessibility profiling identifies principles of epigenetic regulation in 23 primary human cancers.
http://science.sciencemag.org/content/362/6413/eaav1898
934 Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis.
http://stke.sciencemag.org/content/11/552/eaao5150
933 Local generation of hydrogen for enhanced photothermal therapy.
https://www.nature.com/articles/s41467-018-06630-2
932 BAP1 links metabolic regulation of ferroptosis to tumour suppression.
https://www.nature.com/articles/s41556-018-0178-0
931 Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy.
http://science.sciencemag.org/content/362/6411/eaar3593
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