970 Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
https://www.pnas.org/content/116/6/2210
969 Identification and sequencing of circulating tumour DNA in the cerebrospinal fluid of patients with glioma.
https://www.nature.com/articles/s41586-019-0882-3
968 A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors.
https://www.nature.com/articles/s41586-019-0878-z
967 Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
http://advances.sciencemag.org/content/5/1/eaau9060
966 Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01.
http://stm.sciencemag.org/content/11/476/eaat9321
965 Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification
https://www.nature.com/articles/nbt.4313
964 An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma.
https://www.nature.com/articles/nbt.4302
963 Central body fatness is a stronger predictor of cancer risk than overall body size.
https://www.nature.com/articles/s41467-018-08159-w
962 Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation.
https://www.pnas.org/content/116/4/1361
961 Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.
https://www.pnas.org/content/116/4/1370
960 IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses.
https://www.pnas.org/content/116/2/599
959 Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin.
https://www.nature.com/articles/s41586-018-0812-9
958 A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.
https://www.cell.com/cell/fulltext/S0092-8674(18)31622-2
957 Actively personalized vaccination trial for newly diagnosed glioblastoma.
https://www.nature.com/articles/s41586-018-0810-y
956 Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.
https://www.nature.com/articles/s41586-018-0792-9
955 De novo design of potent and selective mimics of IL-2 and IL-15.
https://www.nature.com/articles/s41586-018-0830-7
954 Deletion of the A-to-I double-stranded RNA-editing enzyme ADAR1 sensitizes tumour cells to immunotherapy.
https://www.nature.com/articles/s41586-018-0768-9
953 Organoid Modeling of the Tumor Immune Microenvironment.
https://www.cell.com/cell/fulltext/S0092-8674(18)31513-7
952 Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture.
https://www.pnas.org/content/115/50/E11671
951 Altered ubiquitination of RAS GTPases is implicated in cancer drug resistance.
http://science.sciencemag.org/content/362/6419/1171
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