1190 ACE2 is protective against renal cancer, and its down-modulation by inhibitors of VEGF receptor signaling may mediate resistance to such inhibitors.
https://stm.sciencemag.org/content/13/577/eabc0170
1189 Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer.
https://stm.sciencemag.org/content/13/575/eaba6110
1188 Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9
1187 Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
https://www.nature.com/articles/s41586-020-2911-7
1186 The dose threshold for nanoparticle tumour delivery.
https://www.nature.com/articles/s41563-020-0755-z
1185 Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202005295
1184 Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
https://www.pnas.org/content/117/48/30670
1183 Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
https://www.pnas.org/content/117/48/30566
1182 Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy.
https://stm.sciencemag.org/content/12/571/eaaz6667
1181 Systemic cancer therapy with engineered adenovirus that evades innate immunity.
https://stm.sciencemag.org/content/12/571/eabc6659
1180 CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response.
https://www.pnas.org/content/117/46/28960
1179 Fighting against Drug‐Resistant Tumors using a Dual‐Responsive Pt(IV)/Ru(II) Bimetallic Polymer.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202004766
1178 Serine restriction alters sphingolipid diversity to constrain tumour growth.
https://www.nature.com/articles/s41586-020-2609-x
1177 Expression of the axon-guidance gene Slit2 in endothelium, induced by endothelial sensing of tumour-derived double-stranded RNA, promotes metastatic dissemination in mouse models of breast and lung cancer.
https://www.nature.com/articles/s41586-020-2774-y
1176 The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.
https://www.nature.com/articles/s41586-020-2541-0
1175 B cell acute lymphoblastic leukemia cells mediate RANK-RANKL–dependent bone destruction.
https://stm.sciencemag.org/content/12/561/eaba5942
1174 Interleukin-2 signals converge in a lymphoid–dendritic cell pathway that promotes anticancer immunity.
https://stm.sciencemag.org/content/12/561/eaba5464
1173 The bacterial-derived metabolite inosine enhances cancer immunotherapy in mice.
https://science.sciencemag.org/content/369/6510/1481
1172 Ageing in humans is associated with an increase in circulating methylmalonic acid, which induces expression of SOX4 and promotes tumour progression.
https://www.nature.com/articles/s41586-020-2630-0
1171 An effective combination immunotherapy using oncolytic viruses delivers de novo CD19 to promote CD19-CAR T cell therapy against solid tumors in mice.
https://stm.sciencemag.org/content/12/559/eaaz1863
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