1210 Mitochondrial copper depletion suppresses triple-negative breast cancer in mice.
https://www.nature.com/articles/s41587-020-0707-9
1209 Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression.
https://stke.sciencemag.org/content/14/677/eaax5971
1208 Breast tumours maintain a reservoir of subclonal diversity during expansion.
https://www.nature.com/articles/s41586-021-03357-x
1207 Acute myeloid leukemia cells are dependent on the DNA repair function of valosin-containing protein, opening up an avenue for disease treatment.
https://stm.sciencemag.org/content/13/587/eabg1168
1206 Identification of bacteria-derived HLA-bound peptides in melanoma.
https://www.nature.com/articles/s41586-021-03368-8
1205 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
https://www.pnas.org/content/118/13/e2015433118
1204 A role for keratin 17 during DNA damage response and tumor initiation.
https://www.pnas.org/content/118/13/e2020150118
1203 T cells engineered with synthetic receptors that integrate components of T cell and B cell receptors show efficacy against solid tumors in mice.
https://stm.sciencemag.org/content/13/586/eabb5191
1202 TCR β chain–directed bispecific antibodies for the treatment of T cell cancers.
https://stm.sciencemag.org/content/13/584/eabd3595
1201 RNA interference–based spherical nucleic acid nanoconjugates are a potentially safe and brain-penetrant approach for glioblastoma treatment.
https://stm.sciencemag.org/content/13/584/eabb3945
1200 Identification of a metabolic checkpoint involving lipid signalling that is specific to regulatory T cells (Treg cells) in the tumour microenvironment raises the possibility of targeting this checkpoint for treatment of cancer.
https://www.nature.com/articles/s41586-021-03235-6
1199 In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.
https://www.nature.com/articles/s41586-020-03147-x
1198 Fragmentation patterns of cell-free DNA from urine differ between healthy individuals and those with cancer.
https://stm.sciencemag.org/content/13/581/eaaz3088
1197 Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles.
https://www.pnas.org/content/118/7/e2020575118
1196 Percutaneous liquid ablation agent for tumor treatment and drug delivery.
https://stm.sciencemag.org/content/13/580/eabe3889
1195 Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling.
https://www.pnas.org/content/118/6/e2005191118
1194 Resistance to immunotherapy can be overcome using fecal microbiota transplantation for patients with metastatic melanoma.
https://science.sciencemag.org/content/371/6529/602
1193 Expression of the Epstein–Barr virus protein LMP1 in B cells increases expression of—and promotes T cell responses to—tumour-associated antigens, delineating a mechanism of infection-induced anti-tumour immunity, which could inform immune-based approaches to cancer treatment.
https://www.nature.com/articles/s41586-020-03075-w
1192 Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy.
https://www.pnas.org/content/118/5/e2017421118
1191 Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
https://www.pnas.org/content/118/5/e2020478118
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