32 A mild fluorination method could help produce compounds of interest in medicinal research.
http://www.sciencemag.org/content/342/6161/956.abstract
31 Chemical synthesis of lactic acid from cellulose catalysed by lead(II) ions in water.
http://www.nature.com/ncomms/2013/130711/ncomms3141/full/ncomms3141.html
30 Metal-free oxidation of aromatic carbon–hydrogen bonds through a reverse-rebound mechanism.
http://www.nature.com/nature/journal/v499/n7457/full/nature12284.html
29 Two catalysts independently set the chiral sense of adjacent stereocenters in a carbon–carbon bond-forming reaction.
http://www.sciencemag.org/content/340/6136/1065.abstract
28 An iron catalyst facilitates carbon–nitrogen bond formation in previously unreactive substrates.
http://www.sciencemag.org/content/340/6132/591.abstract
27 Construction of Robust Enzyme Nanocapsules for Effective Organophosphate Decontamination, Detoxification, and Protection.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201205138/abstract
26 A Pictet-Spengler ligation for protein chemical modification.
http://www.pnas.org/content/110/1/46.abstract
25 Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers.
http://www.sciencemag.org/content/338/6112/1324.abstract
24 Carbon dioxide reduction to methane and coupling with acetylene to form propylene catalyzed by remodeled nitrogenase.
http://www.pnas.org/content/109/48/19644.abstract
23 Hydrophobic interactions appear to steer three molecular fragments into a knot, rather than a simpler ring geometry.
http://www.sciencemag.org/content/338/6108/783.abstract
22 The synthesis of an all-carbon quaternary stereocentre in an acyclic system is reported; the chemical transformation involves the formation of two new stereogenic centres—including the challenging all-carbon quaternary one in an aldol adduct—via a combined carbometalation–oxidation reaction, giving a stereodefined trisubstituted enolate.
http://www.nature.com/nature/journal/v490/n7421/full/nature11569.html
21 The de novo generation of benzynes—through a hexadehydro-Diels–Alder reaction—followed by their in situ elaboration is reported; the reaction is metal-free and reagent-free, and reveals new modes of intrinsic benzyne reactivity.
http://www.nature.com/nature/journal/v490/n7419/full/nature11518.html
20 A gold catalyst can link together aromatic rings under very mild conditions.
http://www.sciencemag.org/content/337/6102/1644.abstract
19 A simple, regioselective and enantioselective method for allylating β-diketones has been developed, significantly expanding the pool of easily accessible enantiomerically enriched and functionally complex tertiary carbinols.
http://www.nature.com/nature/journal/v487/n7405/full/nature11189.html
18 Activation of remote meta-C–H bonds assisted by an end-on template.
http://www.nature.com/nature/journal/v486/n7404/full/nature11158.html
17 A low-cost 3D printer is used to combine chemical reactions and the reactor to produce an active ‘reactionware’ system for organic and inorganic synthesis. Active elements such as catalysts can be incorporated into the walls of printed reactors, and other printed-in components that enable electrochemical and spectroscopic analysis can also be included.
http://www.nature.com/nchem/journal/v4/n5/abs/nchem.1313.html
16 Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity.
http://www.nature.com/nchem/journal/v4/n1/abs/nchem.1213.html
15 Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity.
http://www.nature.com/nchem/journal/v4/n1/abs/nchem.1206.html
14 Scalable enantioselective total synthesis of taxanes.
http://www.nature.com/nchem/journal/v4/n1/abs/nchem.1196.html
13 The most complex non-DNA molecular knot prepared so far is self-assembled around a chloride anion from five metal cations, five bis-aldehyde and five bis-amine building blocks, in a one-pot reaction. The X-ray crystal structure of the 160-atom-loop pentafoil knot reveals a symmetrical closed-loop double helicate with a chloride anion held at its centre by ten CH···Cl− hydrogen bonds.
http://www.nature.com/nchem/journal/v4/n1/abs/nchem.1193.html
12 Chemoselective synthesis of ketones and ketimines by addition of organometallic reagents to secondary amides.
http://www.nature.com/nchem/journal/v4/n3/abs/nchem.1268.html
11 A two-dimensional polymer prepared by organic synthesis.
http://www.nature.com/nchem/journal/v4/n4/abs/nchem.1265.html
10 Pyridine-Substituted BODIPY as Fluorescent Probe for Hg2+
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201101839/abstract
9 Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles.
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201101726/abstract
8 Simple Access to Sol–Gel Precursors Bearing Fluorescent Aromatic Core Units.
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200076/abstract
7 Design and Development of Bioinspired Guanine-Based Organic Catalyst for Asymmetric Catalysis.
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200118/abstract
6 Stereocontrol with Lithium Trimethylzincate toward Gibberellin Synthesis.
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200156/abstract
5 Iron(III)-Catalyzed Four-Component Coupling Reaction of 1,3-Dicarbonyl Compounds, Amines, Aldehydes, and Nitroalkanes: A Simple and Direct Synthesis of Functionalized Pyrroles.
http://pubs.acs.org/doi/abs/10.1021/jo902661y
4 Synthesis of O-Spiro-C-Aryl Glycosides Using Organocatalysis.
http://pubs.acs.org/doi/abs/10.1021/jo202353r
3 Synthesis of Allenes via Gold-Catalyzed Intermolecular Reaction of Propargylic Alcohols and Aromatic Compounds.
http://pubs.acs.org/doi/abs/10.1021/jo300147u
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