107 X-ray crystal structures of two distinct steps in the catalytic cycle of non-ribosomal peptide synthetases are described, offering the potential to generate novel products through engineering enzyme activity.
http://www.nature.com/nature/journal/v529/n7585/full/nature16163.html
106 Structure of the voltage-gated calcium channel Cav1.1 complex.
http://www.sciencemag.org/content/350/6267/aad2395.abstract
105 Architecture of the mammalian mechanosensitive Piezo1 channel.
http://www.nature.com/nature/journal/v527/n7576/full/nature15247.html
104 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
http://www.nature.com/nature/journal/v526/n7575/full/nature15375.html
103 Structure and mechanism of the mammalian fructose transporter GLUT5.
http://www.nature.com/nature/journal/v526/n7573/full/nature14909.html
102 Crystal structures of a double-barrelled fluoride ion channel.
http://www.nature.com/nature/journal/v525/n7570/full/nature14981.html
101 The structure of DNA by direct imaging.
http://advances.sciencemag.org/content/1/7/e1500734.full
100 Structure and mechanism of the ATPase that powers viral genome packaging.
http://www.pnas.org/content/112/29/E3792.abstract
99 Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process.
http://www.nature.com/nature/journal/v523/n7560/full/nature14495.html
98 Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.
http://www.nature.com/nature/journal/v523/n7558/full/nature14405.html
97 Electron cryomicroscopy shows structures of three distinct rotational states of the V-ATPase from Saccharomyces cerevisiae.
http://www.nature.com/nature/journal/v521/n7551/full/nature14365.html
96 Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography.
http://www.cell.com/cell/abstract/S0092-8674(15)00428-6
95 Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
http://www.nature.com/nature/journal/v520/n7549/full/nature14138.html
94 Structure of the human 80S ribosome.
http://www.nature.com/nature/journal/v520/n7549/full/nature14427.html
93 Crystal structure of the eukaryotic origin recognition complex.
http://www.nature.com/nature/journal/v519/n7543/full/nature14239.html
92 The structure of the ~400-kD coat nucleoporin complex of yeast is Y-shaped.
http://www.sciencemag.org/content/347/6226/1148.abstract
91 Structure of a left-handed DNA G-quadruplex.
http://www.pnas.org/content/112/9/2729.abstract
90 Structure of the key species in the enzymatic oxidation of methane to methanol.
http://www.nature.com/nature/journal/v518/n7539/full/nature14160.html
89 Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter.
http://www.nature.com/nature/journal/v517/n7534/full/nature13872.html
88 Structure of a mammalian ryanodine receptor.
http://www.nature.com/nature/journal/v517/n7532/full/nature13950.html
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