55  mTORC1 senses nutrient sufficiency by recognizing conformational changes in its lysosomal anchor, heterodimeric Rag GTPase.

54  How internal cavities destabilize a protein.

53  A membrane protein, Shisa7, regulates trafficking, kinetics, and pharmacology of GABAA receptors.

52  YY1 transcriptionally represses TGFB1 in mice and may be a potential drug target for treating diabetic nephropathy.

51  A selective cell-penetrating scorpion toxin targets the irritant receptor, TRPA1, via a distinct biochemical mechanism from that used by irritants, allowing definition of a new mechanism of channel activation and interrogation of pathways of pain sensitization.

50  LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.

49  The plasmodium protein kinase PfCLK3 provides a specific protein kinase target for antimalarial development.

48  Compendium of 4,941 rumen metagenome-assembled genomes for rumen microbiome biology and enzyme discovery.

47  Cholera toxin promotes pathogen acquisition of host-derived nutrients.

46  A technique for the de novo design of switchable protein systems controlled by induced conformational change is demonstrated for three functional motifs, in vitro and in yeast and mammalian cells.

45  Inhibition of natriuretic peptide receptor 1 reduces itch in mice.

44  Allosteric modulation of a human protein kinase with monobodies.

43  In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

42  SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

41  TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.

40  Critical role of spectrin in hearing development and deafness.

39  Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

38  The centrosome protein AKNA regulates neurogenesis via microtubule organization.

37  Microbiome-derived nitric oxide causes widespread post-translational modification of host proteins to regulate host functions and physiology.

36  Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

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