207 On-demand manufacturing of clinical-quality biopharmaceuticals.
https://www.nature.com/articles/nbt.4262
206 Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
http://www.pnas.org/content/115/40/10124
205 Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.
http://stm.sciencemag.org/content/10/460/eaat7520
204 Optimized arylomycins are a new class of Gram-negative antibiotics.
https://www.nature.com/articles/s41586-018-0483-6
203 A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
http://stm.sciencemag.org/content/10/456/eaar3483
202 Suppression of Staphylococcus aureus virulence by a small-molecule compound.
http://www.pnas.org/content/115/31/8003
201 Species-specific activity of antibacterial drug combinations
https://www.nature.com/articles/s41586-018-0278-9
200 A new class of synthetic retinoid antibiotics effective against bacterial persisters.
https://www.nature.com/articles/nature26157
199 Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.
http://science.sciencemag.org/content/359/6373/314
198 The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.
http://stm.sciencemag.org/content/10/423/eaan4044
197 A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
http://science.sciencemag.org/content/358/6368/1332
196 Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
http://www.cell.com/cell/fulltext/S0092-8674(17)31257-6
195 Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
https://www.nature.com/nature/journal/v550/n7677/full/nature24451.html
194 Chemical synthesis yields gram quantities of a scarce compound under study for treating HIV, cancer, and Alzheimer’s disease.
http://science.sciencemag.org/content/358/6360/218
193 Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis.
http://advances.sciencemag.org/content/3/8/e1701102
192 Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents.
https://www.nature.com/articles/s41467-017-00419-5
191 Plasmonic silver nanoshells for drug and metabolite detection.
https://www.nature.com/articles/s41467-017-00220-4
190 Synergy of synthesis, computation and NMR reveals correct baulamycin structures.
http://www.nature.com/nature/journal/v547/n7664/full/nature23265.html
189 Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
http://www.cell.com/cell/fulltext/S0092-8674(17)30709-2
188 A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
https://www.nature.com/articles/s41467-017-00049-x
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