299 Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.
http://www.pnas.org/content/109/49/20101.abstract
298 Rational design of potent domain antibody inhibitors of amyloid fibril assembly.
http://www.pnas.org/content/109/49/19965.abstract
297 Neural basis of contagious itch and why some people are more prone to it.
http://www.pnas.org/content/109/48/19816.abstract
296 A Large-Scale Model of the Functioning Brain.
http://www.sciencemag.org/content/338/6111/1202.abstract
295 Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation.
http://www.cell.com/abstract/S0092-8674(12)01338-4
294 A component of cerebrospinal fluid in excessively sleepy people activates an inhibitory signaling pathway and mimics the actions of sedative-hypnotics.
http://stm.sciencemag.org/content/4/161/161ra151.abstract
293 Light-activated gene therapy acutely suppresses seizures, and gene therapy with a potassium channel prevents epileptogenesis and treats established epilepsy in a rodent model.
http://stm.sciencemag.org/content/4/161/161ra152.abstract
292 Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice.
http://www.sciencemag.org/content/338/6109/949.abstract
291 MicroRNA-223 is neuroprotective by targeting glutamate receptors.
http://www.pnas.org/content/109/46/18962.abstract
290 Cai and colleagues show that the function of adult hypothalamic neural stem cells in mice is impaired following NF-κB activation associated with a chronic high-fat diet, resulting in development of obesity and neurodegenerative features. Mechanistically, NF-κB affects both Notch signalling and apoptosis in these cells.
http://www.nature.com/ncb/journal/v14/n10/abs/ncb2562.html
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