437 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
http://science.sciencemag.org/content/353/6299/594
436 The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA.
http://www.nature.com/nature/journal/v535/n7612/full/nature18622.html
435 Accurate design of megadalton-scale two-component icosahedral protein complexes.
http://science.sciencemag.org/content/353/6297/389
434 Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.
http://www.pnas.org/content/113/28/7840
433 A small core protein of human adenoviruses is shown to associate with histones, sequestering proteins on host chromatin and preventing inflammatory proteins from being released and triggering inflammation.
http://www.nature.com/nature/journal/v535/n7610/full/nature18317.html
432 Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
http://science.sciencemag.org/content/353/6294/78
431 C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
http://science.sciencemag.org/content/early/2016/06/01/science.aaf5573
430 Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.
http://www.pnas.org/content/113/19/5388.abstract
429 A prebiotically reasonable route to synthesize purine RNA bases A and G lends support to the RNA world hypothesis.
http://science.sciencemag.org/content/352/6287/833
428 Argonaute-associated short introns are a novel class of gene regulators.
http://www.nature.com/ncomms/2016/160513/ncomms11538/full/ncomms11538.html
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