467 The application of genome-wide CRISPR–Cas9 screening coupled with a fluorescent reporter to interrogate the microRNA pathway reveals that continual transient phosphorylation of Argonaute 2 is required to maintain the global efficiency of microRNA-mediated repression.
http://www.nature.com/nature/journal/v542/n7640/full/nature21025.html
466 Protein structure determination using metagenome sequence data.
http://science.sciencemag.org/content/355/6322/294
465 Evolutionary drivers of thermoadaptation in enzyme catalysis.
http://science.sciencemag.org/content/355/6322/289?_ga=1.218330778.2031308027.1476376128
464 Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy.
http://www.nature.com/articles/ncomms13913
463 The structure of one of the molecular machines that helps build the ribosome reveals how it partitions ribosomal RNA domains.
http://science.sciencemag.org/content/355/6321/eaal1880
462 SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways.
http://www.nature.com/articles/srep40161
461 Cryo–electron microscopy reveals how lentiviral DNA and the viral integrase assemble to promote retroviral integration into host cell DNA.
http://science.sciencemag.org/content/355/6320/89
460 CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.
http://science.sciencemag.org/content/355/6320/aah7111
459 Translational termination without a stop codon.
http://science.sciencemag.org/content/354/6318/1437
458 A method for CRISPR-based genome editing that harnesses cellular non-homologous end joining activity to achieve targeted DNA knock-in in non-dividing tissues.
http://www.nature.com/nature/journal/v540/n7631/full/nature20565.html
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