507 CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
http://science.sciencemag.org/content/360/6387/436
506 Identification of an ion channel that functions in sour taste sensation in mammals and flies is described.
http://science.sciencemag.org/content/359/6379/1047
505 Cryo-electron microscopy and single-molecule studies reveal that the adaptors BICDR1 and HOOK3 recruit two dynein molecules to dynactin and thereby increase the force and speed of the dynein–dynactin microtubule motor.
https://www.nature.com/articles/nature25462
504 Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation.
http://science.sciencemag.org/content/359/6375/545
503 DNA synthesis from diphosphate substrates by DNA polymerases.
http://www.pnas.org/content/115/5/980
502 Dicer uses distinct modules for recognizing dsRNA termini.
http://science.sciencemag.org/content/359/6373/329
501 The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.
https://www.nature.com/articles/nature25179
500 Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
https://www.nature.com/articles/nature25164
499 An RNA-editing technology is developed to efficiently and specifically deplete and correct RNA directly in mammalian cells.
http://science.sciencemag.org/content/358/6366/1019
498 Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells.
http://www.pnas.org/content/114/47/12560.abstract
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