537 Obesity caused by loss of function of one gene copy can be rescued via CRISPR-mediated activation of the normal copy.
http://science.sciencemag.org/content/363/6424/eaau0629
536 Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.
https://www.pnas.org/content/116/3/960
535 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
https://www.nature.com/articles/s41586-018-0840-5
534 Introns are mediators of cell response to starvation.
https://www.nature.com/articles/s41586-018-0859-7
533 Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
https://www.nature.com/articles/s41586-018-0749-z
532 LZTR1 is a regulator of RAS ubiquitination and signaling.
http://science.sciencemag.org/content/362/6419/1171
531 A DNA methylation reader complex that enhances gene transcription.
http://science.sciencemag.org/content/362/6419/1182
530 CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
https://www.nature.com/articles/s41586-018-0758-y
529 Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion.
http://advances.sciencemag.org/content/4/11/eaau9859
528 The authors use a machine-learning algorithm to predict the spectrum of CRISPR–Cas9-nuclease-mediated DNA repair outcomes at human genomic target sites.
https://www.nature.com/articles/s41586-018-0686-x
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