Molecular Biology


507  CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.

506  Identification of an ion channel that functions in sour taste sensation in mammals and flies is described.

505  Cryo-electron microscopy and single-molecule studies reveal that the adaptors BICDR1 and HOOK3 recruit two dynein molecules to dynactin and thereby increase the force and speed of the dynein–dynactin microtubule motor.

504  Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation.

503  DNA synthesis from diphosphate substrates by DNA polymerases.

502  Dicer uses distinct modules for recognizing dsRNA termini.

501  The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.

500  Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

499  An RNA-editing technology is developed to efficiently and specifically deplete and correct RNA directly in mammalian cells.

498  Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells.

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