417 Capsular polysaccharides (CPS) enclose many pathogenic strains of Escherichia coli, protecting the bacteria from the host. Here, an extracellular blocker of Wza, a pore-forming protein that transports CPS to the cell surface, has been discovered by single-channel electrical recording. Treatment with the blocker exposes the bacterial cell surface and thereby facilitates killing by the human immune system.
http://www.nature.com/nchem/journal/v5/n8/abs/nchem.1695.html
416 Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis.
http://www.pnas.org/content/110/33/13594.abstract
415 Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection.
http://www.pnas.org/content/110/33/E3100.abstract
414 Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome.
http://www.cell.com/cell-host-microbe/abstract/S1931-3128(13)00226-6
413 Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron.
http://www.cell.com/cell-host-microbe/abstract/S1931-3128(13)00223-0
412 A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity.
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003456
411 Single-dose vaccine against tick-borne encephalitis.
http://www.pnas.org/content/110/32/13103.abstract
410 Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains.
http://www.pnas.org/content/110/32/12911.abstract
409 The bacterial pathogen Listeria monocytogenes exploits histone modifications to reprogram its host.
http://www.sciencemag.org/content/341/6145/1238858.abstract
408 Elevated Carbon Monoxide in the Exhaled Breath of Mice during a Systemic Bacterial Infection.
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0069802
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