22 Inhibiting endothelial cell contractility reverses the deleterious effects of age-related matrix stiffening on normal cell function, which could help prevent the development of atherosclerosis.
http://stm.sciencemag.org/content/3/112/112ra122.abstract
21 Aspartate 112 is the selectivity filter of the human voltage-gated proton channel.
http://www.nature.com/nature/journal/v480/n7376/full/nature10557.html
20 Caspase 8 is known to suppress necroptosis, but its relevant target protein was unknown. Ting and colleagues show that caspase 8 cleaves the deubiquitylase CYLD to inhibit necroptosis and promote cell survival.
http://www.nature.com/ncb/journal/v13/n12/abs/ncb2362.html
19 Signaling through Gαi2 induces hypertrophy and can counterbalance pathways that promote muscle wasting.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/201/ra80
18 Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe.
http://stm.sciencemag.org/content/3/110/110ra119.abstract
17 Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death.
http://www.pnas.org/content/108/47/18977.abstract
16 Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.
http://www.pnas.org/content/108/47/E1204.abstract
15 Short double-stranded RNAs induce death in certain cell types without knocking down gene expression.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/198/ra74
14 Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
http://www.nature.com/nature/journal/v479/n7372/full/nature10600.html
13 ER Tubules Mark Sites of Mitochondrial Division.
http://www.sciencemag.org/content/334/6054/358.abstract
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