374 β-Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells.
http://stm.sciencemag.org/content/6/225/225ra28
373 Colorectal cancers that become resistant to EGFR inhibitors through a variety of mechanisms can be effectively treated by inhibiting MEK in conjunction with EGFR.
http://stm.sciencemag.org/content/6/224/224ra26.abstract
372 Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.
http://www.nature.com/nature/journal/v506/n7488/full/nature13038.html
371 Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.
http://www.nature.com/ncomms/2014/140218/ncomms4295/full/ncomms4295.html
370 Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia.
http://www.nature.com/ncomms/2014/140218/ncomms4273/full/ncomms4273.html
369 In vivo discovery of immunotherapy targets in the tumour microenvironment.
http://www.nature.com/nature/journal/v506/n7486/full/nature12988.html
368 The antioxidants acetylcysteine and vitamin E accelerate tumor progression and reduce survival in mouse models of lung cancer by disrupting the ROS-p53 axis.
http://stm.sciencemag.org/content/6/221/221ra15.abstract
367 GRK3 is essential for metastatic cells and promotes prostate tumor progression.
http://www.pnas.org/content/111/4/1521.abstract
366 TRAIL-coated leukocytes that kill cancer cells in the circulation.
http://www.pnas.org/content/111/3/930.abstract
365 Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087064
364 The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis.
http://www.nature.com/ncomms/2014/140123/ncomms4150/full/ncomms4150.html
363 SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.
http://www.nature.com/ncomms/2014/140124/ncomms4159/full/ncomms4159.html
362 An unusual tumor in dogs arose more than 10,000 years ago, and despite a huge mutational burden, its genome has remained stable.
http://www.sciencemag.org/content/343/6169/437.abstract
361 Preventing signaling by ANGPTL2, which is stimulated by the tumor microenvironment, could inhibit metastasis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/309/ra7
360 Large-scale genomic analysis of somatic point mutations in exomes from tumour–normal pairs across 21 cancer types identifies most known cancer genes in these tumour types as well as 33 genes not known to be significantly mutated, and down-sampling analysis indicates that larger sample sizes will reveal many more genes mutated at clinically important frequencies.
http://www.nature.com/nature/journal/v505/n7484/full/nature12912.html
359 Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis.
http://www.cell.com/immunity/abstract/S1074-7613(13)00557-8
358 Barcoding technology enabled measurement of hundreds of cellular proteins from cancer patients with single-cell resolution.
http://stm.sciencemag.org/content/6/219/219ra9.abstract
357 Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells.
http://www.sciencemag.org/content/343/6168/301.abstract
356 The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins.
http://www.sciencemag.org/content/343/6168/305.abstract
355 Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy.
http://pubs.acs.org/doi/abs/10.1021/nn405724x
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