814 Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras.
https://www.nature.com/articles/s41467-017-01019-z
813 Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities.
http://www.nature.com/nbt/journal/v35/n10/abs/nbt.3955.html
812 Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.
http://www.nature.com/nm/journal/v23/n10/abs/nm.4399.html
811 Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.
http://science.sciencemag.org/content/358/6360/234
810 An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors.
http://stm.sciencemag.org/content/9/410/eaal4291
809 Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
http://www.nature.com/nature/journal/v550/n7674/full/nature24028.html
808 Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts.
http://www.pnas.org/content/114/39/E8234
807 Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.
http://www.nature.com/nature/journal/v549/n7673/full/nature23891.html
806 Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.
http://science.sciencemag.org/content/357/6358/1416
805 Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen–specific CTLs.
http://stm.sciencemag.org/content/9/408/eaan4220
804 Tumor-associated B-cells induce tumor heterogeneity and therapy resistance.
https://www.nature.com/articles/s41467-017-00452-4
803 Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.
http://stm.sciencemag.org/content/9/407/eaal4712
802 Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.
http://www.nature.com/nature/journal/v549/n7671/full/nature23666.html
801 Large-scale enhancer reprogramming directed by transcription factors such as FOXA1 drives metastasis in the organoid model of pancreatic cancer.
http://www.cell.com/cell/fulltext/S0092-8674(17)30814-0
800 Distinct tumor immune microenvironments co-exist within a single individual and may help to explain the heterogeneous fates of metastatic lesions often observed post-therapy.
http://www.cell.com/cell/fulltext/S0092-8674(17)30832-2
799 Molecular machines open cell membranes.
http://www.nature.com/nature/journal/v548/n7669/full/nature23657.html?foxtrotcallback=true
798 Identification of essential genes for cancer immunotherapy.
https://www.nature.com/nature/journal/v548/n7669/full/nature23477.html
797 CDK4/6 inhibition triggers anti-tumour immunity.
http://www.nature.com/nature/journal/v548/n7668/full/nature23465.html
796 SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis.
https://www.nature.com/articles/s41467-017-00396-9
795 Ultrastable Near-Infrared Conjugated-Polymer Nanoparticles for Dually Photoactive Tumor Inhibition.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201700487/full
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