1010 ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
https://www.nature.com/articles/s41556-019-0305-6
1009 Engineered immune cells as highly sensitive cancer diagnostics.
https://www.nature.com/articles/s41587-019-0064-8
1008 Interferon-γ induces ferroptotic cell death in tumours by suppressing cystine uptake and promoting lipid peroxidation.
https://www.nature.com/articles/s41586-019-1170-y
1007 Effective PD-1 immunotherapy is influenced by the intensity of tumor microsatellite instability.
https://science.sciencemag.org/content/364/6439/485
1006 In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new target for cancer drug development.
https://www.nature.com/articles/s41586-019-1103-9
1005 A subtype of conventional dendritic cells, cDC2, are able to prime CD4+ T cells for antitumor functions and the presence of cDC2 in human cancer samples may serve as a predictive biomarker for survival and response to immune checkpoint blockade.
https://www.cell.com/cell/fulltext/S0092-8674(19)30154-0
1004 Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state.
https://stm.sciencemag.org/content/11/488/eaav0936
1003 Why does tumor-suppressor BAP1 lead to cancer only in specific tissues?
https://science.sciencemag.org/content/364/6437/283
1002 Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.
https://www.nature.com/articles/s41586-019-1062-1
1001 Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
https://www.nature.com/articles/s41586-019-1005-x
1000 Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice.
https://www.nature.com/articles/s41467-019-09525-y
999 Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.
https://www.nature.com/articles/s41556-019-0298-1
998 Chimeric antigen receptors (CARs) promote antigen loss in tumour cells by trogocytosis, which results in T cell fratricide killing and exhaustion but can be counteracted by cooperative killing and combinatorial targeting.
https://www.nature.com/articles/s41586-019-1054-1
997 Exogenous pyruvate is needed for breast cancer cells to form metastases, and the inhibition of pyruvate metabolism impairs collagen hydroxylation and the growth of lung metastases in different mouse models.
https://www.nature.com/articles/s41586-019-0977-x
996 Deprivation of glutamine in cell culture reveals its potential for treating cancer.
https://www.pnas.org/content/116/14/6964
995 GPRC5D is an attractive target for immunotherapy of myeloma, and optimized GPRC5D-targeted CAR T cells eradicate myeloma xenografts.
http://stm.sciencemag.org/content/11/485/eaau7746
994 T cell stemness and dysfunction in tumors are triggered by a common mechanism.
http://science.sciencemag.org/content/363/6434/eaau0135
993 NR4A transcription factors limit CAR T cell function in solid tumours.
https://www.nature.com/articles/s41586-019-0985-x
992 Glucocorticoids promote breast cancer metastasis.
https://www.nature.com/articles/s41586-019-1019-4
991 A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy.
https://www.nature.com/articles/s41551-019-0363-x
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