Cancer Biology

 
986 Pancreatic cancer activates IL-6–STAT3 signalling in hepatocytes to induce the formation of a pro-metastatic niche in the liver.
https://www.nature.com/articles/s41586-019-1004-y

985 Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
http://stm.sciencemag.org/content/11/482/eaau5612

984 The authors find that loss of squalene monooxygenase expression alters the lipid metabolism of cancer cells, which confers protection from ferroptotic cell death and thus promotes tumour growth.
https://www.nature.com/articles/s41586-019-0945-5

983 Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
https://www.pnas.org/content/116/10/4558

982 The authors show that circulating tumour cells can be found in association with neutrophils, an interaction which supports their proliferation and their ability to seed metastasis.
https://www.nature.com/articles/s41586-019-0915-y

981 The progression of colorectal cancer is fueled by the bile-acid-dependent inhibition of the receptor FXR.
https://www.cell.com/cell/fulltext/S0092-8674(19)30099-6

980 Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
https://www.cell.com/cell/fulltext/S0092-8674(18)31654-4

979 Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways.
https://www.pnas.org/content/116/9/3909

978 Infiltration of CD8+ T cells into tumor cell clusters in triple-negative breast cancer.
https://www.pnas.org/content/116/9/3678

977 Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
https://www.nature.com/articles/s41586-019-0904-1

976 Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma.
https://www.pnas.org/content/116/8/3100

975 Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
https://www.nature.com/articles/s41556-018-0256-3

974 DNA adducts in cells and animals exposed to colibactin-producing gut microbes shed light on the mode of action of a cancer-linked genotoxin.
http://science.sciencemag.org/content/363/6428/eaar7785

973 Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells.
https://www.nature.com/articles/s41586-019-0916-x

972 Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
https://www.sciencedirect.com/science/article/pii/S0092867418316544?via%3Dihub

971 Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.
http://advances.sciencemag.org/content/5/2/eaav5590

970 Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
https://www.pnas.org/content/116/6/2210

969 Identification and sequencing of circulating tumour DNA in the cerebrospinal fluid of patients with glioma.
https://www.nature.com/articles/s41586-019-0882-3

968 A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors.
https://www.nature.com/articles/s41586-019-0878-z

967 Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
http://advances.sciencemag.org/content/5/1/eaau9060

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