1050 CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.
https://www.pnas.org/content/116/31/15635
1049 Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers.
https://www.pnas.org/content/116/31/15524
1048 Engineering nanoparticles to locally activate T cells in the tumor microenvironment.
https://immunology.sciencemag.org/content/4/37/eaau6584
1047 Antioxidants stimulate lung cancer metastasis by reducing free heme levels and stabilizing the transcription factor BACH1.
https://www.cell.com/cell/fulltext/S0092-8674(19)30633-6
1046 The immune response is modulated at a early stage of carcinogenesis, such that both immune activation and evasion precede tumour invasion.
https://www.nature.com/articles/s41586-019-1330-0
1045 Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
https://www.cell.com/cell/fulltext/S0092-8674(19)30631-2
1044 Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function
https://stke.sciencemag.org/content/12/590/eaaw7095
1043 Engineering nanoparticles to locally activate T cells in the tumor microenvironment.
https://immunology.sciencemag.org/content/4/37/eaau6584
1042 Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor.
https://science.sciencemag.org/content/365/6449/162
1041 Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.
https://www.pnas.org/content/116/28/14181
1040 dTcf/Pangolin suppresses growth and tumor formation in Drosophila.
https://www.pnas.org/content/116/28/14055
1039 UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.
https://www.nature.com/articles/s41586-019-1340-y
1038 Programmable bacteria induce durable tumor regression and systemic antitumor immunity.
https://www.nature.com/articles/s41591-019-0498-z
1037 Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30186-X
1036 Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.
https://www.cell.com/immunity/fulltext/S1074-7613(19)30190-6
1035 Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30630-0
1034 A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.
https://www.cell.com/cell/fulltext/S0092-8674(19)30556-2
1033 Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.
https://www.cell.com/cell/fulltext/S0092-8674(19)30510-0
1032 Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.
https://stm.sciencemag.org/content/11/498/eaaw2614
1031 An analysis of more than 2500 human tumors reveals that cancer driver and passenger mutations can be identified from mesoscale genomic context.
https://science.sciencemag.org/content/364/6447/eaaw2872
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