1110 Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies.
https://stm.sciencemag.org/content/12/530/eaax0876
1109 Tobacco smoking and somatic mutations in human bronchial epithelium.
https://www.nature.com/articles/s41586-020-1961-1
1108 Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
https://www.nature.com/articles/s41586-020-1930-8
1107 Pan-cancer analysis of whole genomes.
https://www.nature.com/articles/s41586-020-1969-6
1106 An epigenetic therapy can eliminate preleukemia cells and delay leukemia development in a mouse model.
https://science.sciencemag.org/content/367/6477/586
1105 In a mouse model of glioblastoma, treatment with VEGF-C increases lymphatic drainage in the central nervous system and improves the immune response, suggesting that modulating meningeal lymphatics could enhance checkpoint inhibitor therapy.
https://www.nature.com/articles/s41586-019-1912-x
1104 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/367/6476/446
1103 High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
https://www.pnas.org/content/117/3/1666
1102 Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth.
https://advances.sciencemag.org/content/6/3/eaay2174
1101 Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.
https://stm.sciencemag.org/content/12/526/eaax7992
1100 Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.
https://stm.sciencemag.org/content/12/526/eaax9340
1099 Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
https://www.pnas.org/content/early/2019/12/26/1904022116
1098 HBO1 is required for the maintenance of leukaemia stem cells.
https://www.nature.com/articles/s41586-019-1835-6
1097 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/early/2019/12/30/science.aay5967
1096 Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer.
https://stm.sciencemag.org/content/12/524/eaax7533
1095 An artificial intelligence (AI) system performs as well as or better than radiologists at detecting breast cancer from mammograms, and using a combination of AI and human inputs could help to improve screening efficiency.
https://www.nature.com/articles/s41586-019-1799-6
1094 IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
https://rupress.org/jcb/article-abstract/219/2/e201903017/133547/IPO11-mediates-catenin-nuclear-import-in-a-subset?redirectedFrom=fulltext
1093 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.
https://www.pnas.org/content/116/52/26909
1092 Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
https://www.pnas.org/content/116/52/26580
1091 Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.
https://www.cell.com/cell/fulltext/S0092-8674(19)31269-3
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